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Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.
Waibel M, Solomon VS, Knight DA, Ralli RA, Kim SK, Banks KM, Vidacs E, Virely C, Sia KC, Bracken LS, Collins-Underwood R, Drenberg C, Ramsey LB, Meyer SC, Takiguchi M, Dickins RA, Levine R, Ghysdael J, Dawson MA, Lock RB, Mullighan CG, Johnstone RW. Waibel M, et al. Among authors: johnstone rw. Cell Rep. 2013 Nov 27;5(4):1047-59. doi: 10.1016/j.celrep.2013.10.038. Epub 2013 Nov 21. Cell Rep. 2013. PMID: 24268771 Free PMC article.
Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist.
Frew AJ, Lindemann RK, Martin BP, Clarke CJ, Sharkey J, Anthony DA, Banks KM, Haynes NM, Gangatirkar P, Stanley K, Bolden JE, Takeda K, Yagita H, Secrist JP, Smyth MJ, Johnstone RW. Frew AJ, et al. Among authors: johnstone rw. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11317-22. doi: 10.1073/pnas.0801868105. Epub 2008 Aug 6. Proc Natl Acad Sci U S A. 2008. PMID: 18685088 Free PMC article.
Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.
Wiegmans AP, Alsop AE, Bots M, Cluse LA, Williams SP, Banks KM, Ralli R, Scott CL, Frenzel A, Villunger A, Johnstone RW. Wiegmans AP, et al. Among authors: johnstone rw. Cancer Res. 2011 May 15;71(10):3603-15. doi: 10.1158/0008-5472.CAN-10-3289. Epub 2011 Mar 11. Cancer Res. 2011. PMID: 21398407 Free article.
Cell death research, on an island girt by sea.
Christensen ME, Wong WW, Waibel M, Johnstone RW, Waterhouse NJ. Christensen ME, et al. Among authors: johnstone rw. Cell Death Differ. 2012 Jun;19(6):1090-1. doi: 10.1038/cdd.2012.32. Epub 2012 Mar 16. Cell Death Differ. 2012. PMID: 22421966 Free PMC article. No abstract available.
286 results