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Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy.
Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P. Lewerenz J, et al. Among authors: smolders i. Antioxid Redox Signal. 2014 Jun 20;20(18):2907-22. doi: 10.1089/ars.2013.5455. Epub 2014 Feb 6. Antioxid Redox Signal. 2014. PMID: 24219064 Free PMC article.
Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.
De Bundel D, Schallier A, Loyens E, Fernando R, Miyashita H, Van Liefferinge J, Vermoesen K, Bannai S, Sato H, Michotte Y, Smolders I, Massie A. De Bundel D, et al. Among authors: smolders i. J Neurosci. 2011 Apr 13;31(15):5792-803. doi: 10.1523/JNEUROSCI.5465-10.2011. J Neurosci. 2011. PMID: 21490221 Free PMC article.
The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.
Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P. Lewerenz J, et al. Among authors: smolders i. Antioxid Redox Signal. 2013 Feb 10;18(5):522-55. doi: 10.1089/ars.2011.4391. Epub 2012 Aug 3. Antioxid Redox Signal. 2013. PMID: 22667998 Free PMC article. Review.
Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision.
Bentea E, Demuyser T, Van Liefferinge J, Albertini G, Deneyer L, Nys J, Merckx E, Michotte Y, Sato H, Arckens L, Massie A, Smolders I. Bentea E, et al. Among authors: smolders i. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jun 3;59:49-58. doi: 10.1016/j.pnpbp.2015.01.010. Epub 2015 Jan 23. Prog Neuropsychopharmacol Biol Psychiatry. 2015. PMID: 25619129 Free article.
211 results