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Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Li Y, et al. Among authors: iwatsubo t. Structure. 2014 Jan 7;22(1):125-35. doi: 10.1016/j.str.2013.09.018. Epub 2013 Nov 7. Structure. 2014. PMID: 24210759 Free PMC article.
The role of presenilin cofactors in the gamma-secretase complex.
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. Takasugi N, et al. Among authors: iwatsubo t. Nature. 2003 Mar 27;422(6930):438-41. doi: 10.1038/nature01506. Epub 2003 Mar 16. Nature. 2003. PMID: 12660785
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis.
Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R. Schroeter EH, et al. Among authors: iwatsubo t. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):13075-80. doi: 10.1073/pnas.1735338100. Epub 2003 Oct 17. Proc Natl Acad Sci U S A. 2003. PMID: 14566063 Free PMC article.
606 results