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Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Li Y, et al. Among authors: arimon m. Structure. 2014 Jan 7;22(1):125-35. doi: 10.1016/j.str.2013.09.018. Epub 2013 Nov 7. Structure. 2014. PMID: 24210759 Free PMC article.
The dynamic conformational landscape of gamma-secretase.
Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L. Elad N, et al. Among authors: arimon m. J Cell Sci. 2015 Feb 1;128(3):589-98. doi: 10.1242/jcs.164384. J Cell Sci. 2015. PMID: 25501811 Free PMC article.
Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.
Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Guix FX, et al. Among authors: arimon m. EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2. EMBO Mol Med. 2012. PMID: 22488900 Free PMC article.
15 results