Cavener DR - Search Results

1

25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.

Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, Sullards MC, Murphy RC, Merrill AH Jr, Brown HA, Dennis EA, Fahy E, Subramaniam S, Cavener DR, Spector DH, Russell DW, Glass CK. Shibata N, et al. Among authors: cavener dr. J Biol Chem. 2013 Dec 13;288(50):35812-23. doi: 10.1074/jbc.M113.519637. Epub 2013 Nov 4. J Biol Chem. 2013. PMID: 24189069 Free PMC article.

2

Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis.

Kimball SR, Do AND, Kutzler L, Cavener DR, Jefferson LS. Kimball SR, et al. Among authors: cavener dr. J Biol Chem. 2008 Feb 8;283(6):3465-3475. doi: 10.1074/jbc.M706643200. Epub 2007 Dec 10. J Biol Chem. 2008. PMID: 18070882 Free PMC article.

3

GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase.

Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. Bunpo P, et al. Among authors: cavener dr. J Biol Chem. 2009 Nov 20;284(47):32742-9. doi: 10.1074/jbc.M109.047910. Epub 2009 Sep 25. J Biol Chem. 2009. PMID: 19783659 Free PMC article.

4

The protein kinase PERK/EIF2AK3 regulates proinsulin processing not via protein synthesis but by controlling endoplasmic reticulum chaperones.

Sowers CR, Wang R, Bourne RA, McGrath BC, Hu J, Bevilacqua SC, Paton JC, Paton AW, Collardeau-Frachon S, Nicolino M, Cavener DR. Sowers CR, et al. Among authors: cavener dr. J Biol Chem. 2018 Apr 6;293(14):5134-5149. doi: 10.1074/jbc.M117.813790. Epub 2018 Feb 14. J Biol Chem. 2018. PMID: 29444822 Free PMC article.

5

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Anthony TG, et al. Among authors: cavener dr. J Biol Chem. 2004 Aug 27;279(35):36553-61. doi: 10.1074/jbc.M404559200. Epub 2004 Jun 22. J Biol Chem. 2004. PMID: 15213227 Free article.

6

Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin.

Wang R, McGrath BC, Kopp RF, Roe MW, Tang X, Chen G, Cavener DR. Wang R, et al. Among authors: cavener dr. J Biol Chem. 2013 Nov 22;288(47):33824-33836. doi: 10.1074/jbc.M113.503664. Epub 2013 Oct 10. J Biol Chem. 2013. PMID: 24114838 Free PMC article.

7

Endoplasmic reticulum stress response mediated by the PERK-eIF2(alpha)-ATF4 pathway is involved in osteoblast differentiation induced by BMP2.

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR, Imaizumi K. Saito A, et al. Among authors: cavener dr. J Biol Chem. 2011 Feb 11;286(6):4809-18. doi: 10.1074/jbc.M110.152900. Epub 2010 Dec 6. J Biol Chem. 2011. PMID: 21135100 Free PMC article.

8

eIF2alpha kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver.

Dang Do AN, Kimball SR, Cavener DR, Jefferson LS. Dang Do AN, et al. Among authors: cavener dr. Physiol Genomics. 2009 Aug 7;38(3):328-41. doi: 10.1152/physiolgenomics.90396.2008. Epub 2009 Jun 9. Physiol Genomics. 2009. PMID: 19509078 Free PMC article.

9

GCN2 in the brain programs PPARγ2 and triglyceride storage in the liver during perinatal development in response to maternal dietary fat.

Xu X, Hu J, McGrath BC, Cavener DR. Xu X, et al. Among authors: cavener dr. PLoS One. 2013 Oct 10;8(10):e75917. doi: 10.1371/journal.pone.0075917. eCollection 2013. PLoS One. 2013. PMID: 24130751 Free PMC article.

10

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. Jiang HY, et al. Among authors: cavener dr. Mol Cell Biol. 2004 Feb;24(3):1365-77. doi: 10.1128/MCB.24.3.1365-1377.2004. Mol Cell Biol. 2004. PMID: 14729979 Free PMC article.

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