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Structure-activity relationship study around guanabenz identifies two derivatives retaining antiprion activity but having lost α2-adrenergic receptor agonistic activity.
Nguyen PH, Hammoud H, Halliez S, Pang Y, Evrard J, Schmitt M, Oumata N, Bourguignon JJ, Sanyal S, Beringue V, Blondel M, Bihel F, Voisset C. Nguyen PH, et al. Among authors: oumata n. ACS Chem Neurosci. 2014 Oct 15;5(10):1075-82. doi: 10.1021/cn5001588. Epub 2014 Sep 22. ACS Chem Neurosci. 2014. PMID: 25244284
The toll-like receptor agonist imiquimod is active against prions.
Oumata N, Nguyen PH, Beringue V, Soubigou F, Pang Y, Desban N, Massacrier C, Morel Y, Paturel C, Contesse MA, Bouaziz S, Sanyal S, Galons H, Blondel M, Voisset C. Oumata N, et al. PLoS One. 2013 Aug 16;8(8):e72112. doi: 10.1371/journal.pone.0072112. eCollection 2013. PLoS One. 2013. PMID: 23977222 Free PMC article.
Aftins increase amyloid-β42, lower amyloid-β38, and do not alter amyloid-β40 extracellular production in vitro: toward a chemical model of Alzheimer's disease?
Hochard A, Oumata N, Bettayeb K, Gloulou O, Fant X, Durieu E, Buron N, Porceddu M, Borgne-Sanchez A, Galons H, Flajolet M, Meijer L. Hochard A, et al. Among authors: oumata n. J Alzheimers Dis. 2013;35(1):107-20. doi: 10.3233/JAD-121777. J Alzheimers Dis. 2013. PMID: 23364140 Free PMC article.
Cyclin-dependent kinase inhibitors closer to market launch?
Galons H, Oumata N, Gloulou O, Meijer L. Galons H, et al. Among authors: oumata n. Expert Opin Ther Pat. 2013 Aug;23(8):945-63. doi: 10.1517/13543776.2013.789861. Epub 2013 Apr 22. Expert Opin Ther Pat. 2013. PMID: 23600454 Review.
37 results