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Acetylcholinesterase inhibitors: SAR and kinetic studies on omega-[N-methyl-N-(3-alkylcarbamoyloxyphenyl)methyl]aminoalkoxyaryl derivatives.
Rampa A, Piazzi L, Belluti F, Gobbi S, Bisi A, Bartolini M, Andrisano V, Cavrini V, Cavalli A, Recanatini M, Valenti P. Rampa A, et al. J Med Chem. 2001 Nov 8;44(23):3810-20. doi: 10.1021/jm010914b. J Med Chem. 2001. PMID: 11689067
In this work, we further investigated a class of carbamic cholinesterase inhibitors introduced in a previous paper (Rampa et al. ...The structural modifications lead to a compound (12b) showing an IC(50) value for the AChE inhibition of 0.32 +/- 0.09 n …
In this work, we further investigated a class of carbamic cholinesterase inhibitors introduced in a previous paper (Rampa …
3-(4-[[Benzyl(methyl)amino]methyl]phenyl)-6,7-dimethoxy-2H-2-chromenone (AP2238) inhibits both acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation: a dual function lead for Alzheimer's disease therapy.
Piazzi L, Rampa A, Bisi A, Gobbi S, Belluti F, Cavalli A, Bartolini M, Andrisano V, Valenti P, Recanatini M. Piazzi L, et al. Among authors: rampa a. J Med Chem. 2003 Jun 5;46(12):2279-82. doi: 10.1021/jm0340602. J Med Chem. 2003. PMID: 12773032
Cholinesterase inhibitors: xanthostigmine derivatives blocking the acetylcholinesterase-induced beta-amyloid aggregation.
Belluti F, Rampa A, Piazzi L, Bisi A, Gobbi S, Bartolini M, Andrisano V, Cavalli A, Recanatini M, Valenti P. Belluti F, et al. Among authors: rampa a. J Med Chem. 2005 Jun 30;48(13):4444-56. doi: 10.1021/jm049515h. J Med Chem. 2005. PMID: 15974596
In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. ...The key feature of these derivatives is a 2-arylidenebenzocycloalkanone moiety that provides the ability to bind at the AChE peripheral site …
In continuing research that led us to identify a new class of carbamate derivatives acting as potent (Rampa et al. ...The key …
110 results