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Novel continuous flow technology for the development of a nanostructured aprepitant formulation with improved pharmacokinetic properties.
Eur J Pharm Biopharm. 2014 Apr;86(3):361-8. doi: 10.1016/j.ejpb.2013.10.004. Epub 2013 Oct 22.
Eur J Pharm Biopharm. 2014.
PMID: 24161498
Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates substantial positive food effect.
Solymosi T, Ötvös Z, Angi R, Ordasi B, Jordán T, Molnár L, McDermott J, Zann V, Church A, Mair S, Filipcsei G, Heltovics G, Glavinas H.
Solymosi T, et al. Among authors: ordasi b.
Cancer Chemother Pharmacol. 2017 Oct;80(4):723-728. doi: 10.1007/s00280-017-3406-6. Epub 2017 Aug 3.
Cancer Chemother Pharmacol. 2017.
PMID: 28776077
Clinical Trial.
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Development of an abiraterone acetate formulation with improved oral bioavailability guided by absorption modeling based on in vitro dissolution and permeability measurements.
Solymosi T, Ötvös Z, Angi R, Ordasi B, Jordán T, Semsey S, Molnár L, Ránky S, Filipcsei G, Heltovics G, Glavinas H.
Solymosi T, et al. Among authors: ordasi b.
Int J Pharm. 2017 Oct 30;532(1):427-434. doi: 10.1016/j.ijpharm.2017.09.031. Epub 2017 Sep 15.
Int J Pharm. 2017.
PMID: 28919099
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Dose Escalation Study to Assess the Pharmacokinetic Parameters of a Nano-amorphous Oral Sirolimus Formulation in Healthy Volunteers.
Basa-Dénes O, Angi R, Kárpáti B, Jordán T, Ötvös Z, Erdősi N, Ujhelyi A, Ordasi B, Molnár L, McDermott J, Roe C, McKenzie L, Solymosi T, Heltovics G, Glavinas H.
Basa-Dénes O, et al. Among authors: ordasi b.
Eur J Drug Metab Pharmacokinet. 2019 Dec;44(6):777-785. doi: 10.1007/s13318-019-00562-y.
Eur J Drug Metab Pharmacokinet. 2019.
PMID: 31089971
Clinical Trial.
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