Khosla C - Search Results

1

Metabolic flux between unsaturated and saturated fatty acids is controlled by the FabA:FabB ratio in the fully reconstituted fatty acid biosynthetic pathway of Escherichia coli.

Xiao X, Yu X, Khosla C. Xiao X, et al. Among authors: khosla c. Biochemistry. 2013 Nov 19;52(46):8304-12. doi: 10.1021/bi401116n. Epub 2013 Nov 4. Biochemistry. 2013. PMID: 24147979 Free PMC article.

2

Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase.

Fu H, Alvarez MA, Khosla C, Bailey JE. Fu H, et al. Among authors: khosla c. Biochemistry. 1996 May 28;35(21):6527-32. doi: 10.1021/bi952957y. Biochemistry. 1996. PMID: 8639600

3

Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.

Pieper R, Ebert-Khosla S, Cane D, Khosla C. Pieper R, et al. Among authors: khosla c. Biochemistry. 1996 Feb 20;35(7):2054-60. doi: 10.1021/bi952860b. Biochemistry. 1996. PMID: 8652546

4

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase.

Kao CM, Pieper R, Cane DE, Khosla C. Kao CM, et al. Among authors: khosla c. Biochemistry. 1996 Sep 24;35(38):12363-8. doi: 10.1021/bi9616312. Biochemistry. 1996. PMID: 8823171

5

6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.

Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE. Tsukamoto N, et al. Among authors: khosla c. Biochemistry. 1996 Dec 3;35(48):15244-8. doi: 10.1021/bi961972f. Biochemistry. 1996. PMID: 8952473

6

Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.

Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C. Pieper R, et al. Among authors: khosla c. Biochemistry. 1997 Feb 18;36(7):1846-51. doi: 10.1021/bi962324z. Biochemistry. 1997. PMID: 9048569

7

Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase.

Carreras CW, Gehring AM, Walsh CT, Khosla C. Carreras CW, et al. Among authors: khosla c. Biochemistry. 1997 Sep 30;36(39):11757-61. doi: 10.1021/bi971350+. Biochemistry. 1997. PMID: 9305965

8

Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase.

Gokhale RS, Lau J, Cane DE, Khosla C. Gokhale RS, et al. Among authors: khosla c. Biochemistry. 1998 Feb 24;37(8):2524-8. doi: 10.1021/bi971887n. Biochemistry. 1998. PMID: 9485401

9

Purification and in vitro reconstitution of the essential protein components of an aromatic polyketide synthase.

Carreras CW, Khosla C. Carreras CW, et al. Among authors: khosla c. Biochemistry. 1998 Feb 24;37(8):2084-8. doi: 10.1021/bi972919+. Biochemistry. 1998. PMID: 9518007

10

Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis.

Jacobsen JR, Cane DE, Khosla C. Jacobsen JR, et al. Among authors: khosla c. Biochemistry. 1998 Apr 7;37(14):4928-34. doi: 10.1021/bi9729920. Biochemistry. 1998. PMID: 9538011

Tolerance of the "shortened" intermediates in the biosynthesis of this triketide, in combination with results reported elsewhere [Jacobsen, J. R., Hutchinson, C. R., Cane, D. E., and Khosla, C. (1997) Science 277, 367-369], suggests that relaxed substrate spe …

Tolerance of the "shortened" intermediates in the biosynthesis of this triketide, in combination with results reported elsewhere [Jacobsen, …

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