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Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes.
Hinchliffe P, González MM, Mojica MF, González JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J. Hinchliffe P, et al. Among authors: castillo v. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi: 10.1073/pnas.1601368113. Epub 2016 Jun 14. Proc Natl Acad Sci U S A. 2016. PMID: 27303030 Free PMC article.
Rational Design of Benzobisheterocycle Metallo-β-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes.
Villamil V, Rossi MA, Mojica MF, Hinchliffe P, Martínez V, Castillo V, Saiz C, Banchio C, Macías MA, Spencer J, Bonomo RA, Vila A, Moreno DM, Mahler G. Villamil V, et al. Among authors: castillo v. J Med Chem. 2024 Mar 14;67(5):3795-3812. doi: 10.1021/acs.jmedchem.3c02209. Epub 2024 Feb 19. J Med Chem. 2024. PMID: 38373290
Bisthiazolidines: A Substrate-Mimicking Scaffold as an Inhibitor of the NDM-1 Carbapenemase.
González MM, Kosmopoulou M, Mojica MF, Castillo V, Hinchliffe P, Pettinati I, Brem J, Schofield CJ, Mahler G, Bonomo RA, Llarrull LI, Spencer J, Vila AJ. González MM, et al. Among authors: castillo v. ACS Infect Dis. 2015 Nov 13;1(11):544-54. doi: 10.1021/acsinfecdis.5b00046. Epub 2015 Jul 20. ACS Infect Dis. 2015. PMID: 27623409 Free PMC article.
[GLUT-1 deficiency syndrome].
Zavala M, Castillo V, Gonzalez M, Castillo S. Zavala M, et al. Among authors: castillo s, castillo v. Rev Neurol. 2019 Aug 16;69(4):178-179. doi: 10.33588/rn.6904.2019126. Rev Neurol. 2019. PMID: 31334562 Free article. Review. Spanish.
Correction: 2-Mercaptomethyl-thiazolidines use conserved aromatic-S interactions to achieve broad-range inhibition of metallo-β-lactamases.
Rossi MA, Martinez V, Hinchliffe P, Mojica MF, Castillo V, Moreno DM, Smith R, Spellberg B, Drusano GL, Banchio C, Bonomo RA, Spencer J, Vila AJ, Mahler G. Rossi MA, et al. Among authors: castillo v. Chem Sci. 2023 Aug 15;14(34):9226. doi: 10.1039/d3sc90150e. eCollection 2023 Aug 30. Chem Sci. 2023. PMID: 37655038 Free PMC article.
Clear cell renal cell carcinoma with high PSMA uptake.
Yepes MM, Herrera Ortiz AF, Del Castillo V, Rojas J. Yepes MM, et al. Among authors: del castillo v. BMJ Case Rep. 2024 Apr 24;17(4):e260372. doi: 10.1136/bcr-2024-260372. BMJ Case Rep. 2024. PMID: 38663894 No abstract available.
281 results