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Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity.
Renck D, Machado P, Souto AA, Rosado LA, Erig T, Campos MM, Farias CB, Roesler R, Timmers LF, de Souza ON, Santos DS, Basso LA. Renck D, et al. Among authors: de souza on. J Med Chem. 2013 Nov 14;56(21):8892-902. doi: 10.1021/jm401389u. Epub 2013 Oct 31. J Med Chem. 2013. PMID: 24131420
Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice.
Lobo MM, Oliveira SM, Brusco I, Machado P, Timmers LF, de Souza ON, Martins MA, Bonacorso HG, Dos Santos JM, Canova B, da Silva TV, Zanatta N. Lobo MM, et al. Among authors: de souza on. Eur J Med Chem. 2015 Sep 18;102:143-52. doi: 10.1016/j.ejmech.2015.07.036. Epub 2015 Jul 23. Eur J Med Chem. 2015. PMID: 26263246
Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme.
Martinelli LKB, Rotta M, Villela AD, Rodrigues-Junior VS, Abbadi BL, Trindade RV, Petersen GO, Danesi GM, Nery LR, Pauli I, Campos MM, Bonan CD, de Souza ON, Basso LA, Santos DS. Martinelli LKB, et al. Among authors: de souza on. Sci Rep. 2017 Apr 24;7:46696. doi: 10.1038/srep46696. Sci Rep. 2017. PMID: 28436453 Free PMC article.
Biochemical characterization of recombinant nucleoside hydrolase from Mycobacterium tuberculosis H37Rv.
Wink PL, Sanchez Quitian ZA, Rosado LA, Rodrigues Vda S Jr, Petersen GO, Lorenzini DM, Lipinski-Paes T, Saraiva Macedo Timmers LF, de Souza ON, Basso LA, Santos DS. Wink PL, et al. Among authors: de souza on. Arch Biochem Biophys. 2013 Oct 15;538(2):80-94. doi: 10.1016/j.abb.2013.08.011. Epub 2013 Aug 26. Arch Biochem Biophys. 2013. PMID: 23988349 Free article.
Crystallographic and pre-steady-state kinetics studies on binding of NADH to wild-type and isoniazid-resistant enoyl-ACP(CoA) reductase enzymes from Mycobacterium tuberculosis.
Oliveira JS, Pereira JH, Canduri F, Rodrigues NC, de Souza ON, de Azevedo WF Jr, Basso LA, Santos DS. Oliveira JS, et al. Among authors: de azevedo wf jr, de souza on. J Mol Biol. 2006 Jun 9;359(3):646-66. doi: 10.1016/j.jmb.2006.03.055. Epub 2006 Apr 21. J Mol Biol. 2006. PMID: 16647717
33 results