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Design and microwave-assisted synthesis of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles: novel agents with analgesic and anti-inflammatory properties.
Sauzem PD, Machado P, Rubin MA, da S Sant'anna G, Faber HB, de Souza AH, Mello CF, Beck P, Burrow RA, Bonacorso HG, Zanatta N, Martins MA. Sauzem PD, et al. Among authors: machado p. Eur J Med Chem. 2008 Jun;43(6):1237-47. doi: 10.1016/j.ejmech.2007.07.018. Epub 2007 Aug 15. Eur J Med Chem. 2008. PMID: 17889969
Targeting the histidine pathway in Mycobacterium tuberculosis.
Lunardi J, Nunes JE, Bizarro CV, Basso LA, Santos DS, Machado P. Lunardi J, et al. Among authors: machado p. Curr Top Med Chem. 2013;13(22):2866-84. doi: 10.2174/15680266113136660203. Curr Top Med Chem. 2013. PMID: 24111909 Review.
Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice.
Lobo MM, Oliveira SM, Brusco I, Machado P, Timmers LF, de Souza ON, Martins MA, Bonacorso HG, Dos Santos JM, Canova B, da Silva TV, Zanatta N. Lobo MM, et al. Among authors: machado p. Eur J Med Chem. 2015 Sep 18;102:143-52. doi: 10.1016/j.ejmech.2015.07.036. Epub 2015 Jul 23. Eur J Med Chem. 2015. PMID: 26263246
2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains.
Pissinate K, Villela AD, Rodrigues-Junior V, Giacobbo BC, Grams ES, Abbadi BL, Trindade RV, Roesler Nery L, Bonan CD, Back DF, Campos MM, Basso LA, Santos DS, Machado P. Pissinate K, et al. Among authors: machado p. ACS Med Chem Lett. 2016 Jan 11;7(3):235-9. doi: 10.1021/acsmedchemlett.5b00324. eCollection 2016 Mar 10. ACS Med Chem Lett. 2016. PMID: 26985307 Free PMC article.
New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis.
Giacobbo BC, Pissinate K, Rodrigues-Junior V, Villela AD, Grams ES, Abbadi BL, Subtil FT, Sperotto N, Trindade RV, Back DF, Campos MM, Basso LA, Machado P, Santos DS. Giacobbo BC, et al. Among authors: machado p. Eur J Med Chem. 2017 Jan 27;126:491-501. doi: 10.1016/j.ejmech.2016.11.048. Epub 2016 Nov 23. Eur J Med Chem. 2017. PMID: 27914363
1,028 results