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A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1.
PLoS One. 2013 Oct 10;8(10):e76280. doi: 10.1371/journal.pone.0076280. eCollection 2013.
PLoS One. 2013.
PMID: 24130766
Free PMC article.
TAK-875, a GPR40/FFAR1 agonist, in combination with metformin prevents progression of diabetes and β-cell dysfunction in Zucker diabetic fatty rats.
Ito R, Tsujihata Y, Matsuda-Nagasumi K, Mori I, Negoro N, Takeuchi K.
Ito R, et al. Among authors: matsuda nagasumi k.
Br J Pharmacol. 2013 Oct;170(3):568-80. doi: 10.1111/bph.12297.
Br J Pharmacol. 2013.
PMID: 23848179
Free PMC article.
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Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition.
Matsuda-Nagasumi K, Takami-Esaki R, Iwachidow K, Yasuhara Y, Tanaka H, Ogi K, Nakata M, Yano T, Hinuma S, Taketomi S, Odaka H, Kaisho Y.
Matsuda-Nagasumi K, et al.
Diabetes Obes Metab. 2013 Jun;15(6):538-45. doi: 10.1111/dom.12065. Epub 2013 Feb 6.
Diabetes Obes Metab. 2013.
PMID: 23331570
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