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Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies.
Ebbesen P, Pettersen EO, Gorr TA, Jobst G, Williams K, Kieninger J, Wenger RH, Pastorekova S, Dubois L, Lambin P, Wouters BG, Van Den Beucken T, Supuran CT, Poellinger L, Ratcliffe P, Kanopka A, Görlach A, Gasmann M, Harris AL, Maxwell P, Scozzafava A. Ebbesen P, et al. Among authors: lambin p. J Enzyme Inhib Med Chem. 2009 Apr;24 Suppl 1:1-39. doi: 10.1080/14756360902784425. J Enzyme Inhib Med Chem. 2009. PMID: 19330638 Free article. Review.
Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.
van den Beucken T, Koritzinsky M, Niessen H, Dubois L, Savelkouls K, Mujcic H, Jutten B, Kopacek J, Pastorekova S, van der Kogel AJ, Lambin P, Voncken W, Rouschop KM, Wouters BG. van den Beucken T, et al. Among authors: lambin p. J Biol Chem. 2009 Sep 4;284(36):24204-12. doi: 10.1074/jbc.M109.006510. Epub 2009 Jun 29. J Biol Chem. 2009. PMID: 19564335 Free PMC article.
Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation.
Dubois L, Peeters S, Lieuwes NG, Geusens N, Thiry A, Wigfield S, Carta F, McIntyre A, Scozzafava A, Dogné JM, Supuran CT, Harris AL, Masereel B, Lambin P. Dubois L, et al. Among authors: lambin p. Radiother Oncol. 2011 Jun;99(3):424-31. doi: 10.1016/j.radonc.2011.05.045. Epub 2011 Jun 14. Radiother Oncol. 2011. PMID: 21676479 Free article.
Targeting carbonic anhydrase IX by nitroimidazole based sulfamides enhances the therapeutic effect of tumor irradiation: a new concept of dual targeting drugs.
Dubois L, Peeters SG, van Kuijk SJ, Yaromina A, Lieuwes NG, Saraya R, Biemans R, Rami M, Parvathaneni NK, Vullo D, Vooijs M, Supuran CT, Winum JY, Lambin P. Dubois L, et al. Among authors: lambin p. Radiother Oncol. 2013 Sep;108(3):523-8. doi: 10.1016/j.radonc.2013.06.018. Epub 2013 Jul 9. Radiother Oncol. 2013. PMID: 23849171 Free article.
777 results