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Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
P SH, Solapure S, Mukherjee K, Nandi V, Waterson D, Shandil R, Balganesh M, Sambandamurthy VK, Raichurkar AK, Deshpande A, Ghosh A, Awasthy D, Shanbhag G, Sheikh G, McMiken H, Puttur J, Reddy J, Werngren J, Read J, Kumar M, R M, Chinnapattu M, Madhavapeddi P, Manjrekar P, Basu R, Gaonkar S, Sharma S, Hoffner S, Humnabadkar V, Subbulakshmi V, Panduga V. P SH, et al. Among authors: balganesh m. Antimicrob Agents Chemother. 2014;58(1):61-70. doi: 10.1128/AAC.01751-13. Epub 2013 Oct 14. Antimicrob Agents Chemother. 2014. PMID: 24126580 Free PMC article.
Bactericidal activity and mechanism of action of AZD5847, a novel oxazolidinone for treatment of tuberculosis.
Balasubramanian V, Solapure S, Iyer H, Ghosh A, Sharma S, Kaur P, Deepthi R, Subbulakshmi V, Ramya V, Ramachandran V, Balganesh M, Wright L, Melnick D, Butler SL, Sambandamurthy VK. Balasubramanian V, et al. Among authors: balganesh m. Antimicrob Agents Chemother. 2014;58(1):495-502. doi: 10.1128/AAC.01903-13. Epub 2013 Nov 4. Antimicrob Agents Chemother. 2014. PMID: 24189255 Free PMC article.
In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis.
Solapure S, Dinesh N, Shandil R, Ramachandran V, Sharma S, Bhattacharjee D, Ganguly S, Reddy J, Ahuja V, Panduga V, Parab M, Vishwas KG, Kumar N, Balganesh M, Balasubramanian V. Solapure S, et al. Among authors: balganesh m. Antimicrob Agents Chemother. 2013 Jun;57(6):2506-10. doi: 10.1128/AAC.00023-13. Epub 2013 Mar 18. Antimicrob Agents Chemother. 2013. PMID: 23507276 Free PMC article.
Antituberculosis drugs: reducing efflux=increasing activity.
Rodrigues L, Parish T, Balganesh M, Ainsa JA. Rodrigues L, et al. Among authors: balganesh m. Drug Discov Today. 2017 Mar;22(3):592-599. doi: 10.1016/j.drudis.2017.01.002. Epub 2017 Jan 13. Drug Discov Today. 2017. PMID: 28089787 Review.
17 results