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Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.
Soares J, Pereira NA, Monteiro Â, Leão M, Bessa C, Dos Santos DJ, Raimundo L, Queiroz G, Bisio A, Inga A, Pereira C, Santos MM, Saraiva L. Soares J, et al. Among authors: inga a. Eur J Pharm Sci. 2015 Jan 23;66:138-47. doi: 10.1016/j.ejps.2014.10.006. Epub 2014 Oct 13. Eur J Pharm Sci. 2015. PMID: 25312347
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
Soares J, Raimundo L, Pereira NA, Monteiro Â, Gomes S, Bessa C, Pereira C, Queiroz G, Bisio A, Fernandes J, Gomes C, Reis F, Gonçalves J, Inga A, Santos MM, Saraiva L. Soares J, et al. Among authors: inga a. Oncotarget. 2016 Jan 26;7(4):4326-43. doi: 10.18632/oncotarget.6775. Oncotarget. 2016. PMID: 26735173 Free PMC article.
SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
Gomes S, Bosco B, Loureiro JB, Ramos H, Raimundo L, Soares J, Nazareth N, Barcherini V, Domingues L, Oliveira C, Bisio A, Piazza S, Bauer MR, Brás JP, Almeida MI, Gomes C, Reis F, Fersht AR, Inga A, Santos MMM, Saraiva L. Gomes S, et al. Among authors: inga a. Cancers (Basel). 2019 Aug 10;11(8):1151. doi: 10.3390/cancers11081151. Cancers (Basel). 2019. PMID: 31405179 Free PMC article.
Structural and Drug Targeting Insights on Mutant p53.
Gomes AS, Ramos H, Inga A, Sousa E, Saraiva L. Gomes AS, et al. Among authors: inga a. Cancers (Basel). 2021 Jul 3;13(13):3344. doi: 10.3390/cancers13133344. Cancers (Basel). 2021. PMID: 34283062 Free PMC article. Review.
140 results