Tyrrell DL - Search Results

1

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

Barakat KH, Law J, Prunotto A, Magee WC, Evans DH, Tyrrell DL, Tuszynski J, Houghton M. Barakat KH, et al. Among authors: tyrrell dl. J Chem Inf Model. 2013 Nov 25;53(11):3031-43. doi: 10.1021/ci4003969. Epub 2013 Oct 24. J Chem Inf Model. 2013. PMID: 24116674

2

A Refined Model of the HCV NS5A protein bound to daclatasvir explains drug-resistant mutations and activity against divergent genotypes.

Barakat KH, Anwar-Mohamed A, Tuszynski JA, Robins MJ, Tyrrell DL, Houghton M. Barakat KH, et al. Among authors: tyrrell dl. J Chem Inf Model. 2015 Feb 23;55(2):362-73. doi: 10.1021/ci400631n. Epub 2014 Apr 14. J Chem Inf Model. 2015. PMID: 24730573

3

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase.

Freedman H, Kundu J, Tchesnokov EP, Law JLM, Nieman JA, Schinazi RF, Tyrrell DL, Gotte M, Houghton M. Freedman H, et al. Among authors: tyrrell dl. J Chem Inf Model. 2020 Dec 28;60(12):6566-6578. doi: 10.1021/acs.jcim.0c00742. Epub 2020 Dec 1. J Chem Inf Model. 2020. PMID: 33259199 Free PMC article.

4

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Anwar-Mohamed A, Barakat KH, Bhat R, Noskov SY, Tyrrell DL, Tuszynski JA, Houghton M. Anwar-Mohamed A, et al. Among authors: tyrrell dl. Toxicol Lett. 2014 Nov 4;230(3):382-92. doi: 10.1016/j.toxlet.2014.08.007. Epub 2014 Aug 13. Toxicol Lett. 2014. PMID: 25127758

5

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase.

Freedman H, Winter P, Tuszynski J, Tyrrell DL, Houghton M. Freedman H, et al. Among authors: tyrrell dl. J Biol Chem. 2018 Jun 22;293(25):9696-9705. doi: 10.1074/jbc.RA118.002588. Epub 2018 May 8. J Biol Chem. 2018. PMID: 29739852 Free PMC article.

6

Human serum leads to differentiation of human hepatoma cells, restoration of very-low-density lipoprotein secretion, and a 1000-fold increase in HCV Japanese fulminant hepatitis type 1 titers.

Steenbergen RH, Joyce MA, Thomas BS, Jones D, Law J, Russell R, Houghton M, Tyrrell DL. Steenbergen RH, et al. Among authors: tyrrell dl. Hepatology. 2013 Dec;58(6):1907-17. doi: 10.1002/hep.26566. Epub 2013 Oct 17. Hepatology. 2013. PMID: 23775894

7

Recombinant hepatitis C virus envelope glycoprotein vaccine elicits antibodies targeting multiple epitopes on the envelope glycoproteins associated with broad cross-neutralization.

Wong JA, Bhat R, Hockman D, Logan M, Chen C, Levin A, Frey SE, Belshe RB, Tyrrell DL, Law JL, Houghton M. Wong JA, et al. Among authors: tyrrell dl. J Virol. 2014 Dec;88(24):14278-88. doi: 10.1128/JVI.01911-14. Epub 2014 Oct 1. J Virol. 2014. PMID: 25275133 Free PMC article.

8

A Recombinant Hepatitis C Virus Genotype 1a E1/E2 Envelope Glycoprotein Vaccine Elicits Antibodies That Differentially Neutralize Closely Related 2a Strains through Interactions of the N-Terminal Hypervariable Region 1 of E2 with Scavenger Receptor B1.

Johnson J, Freedman H, Logan M, Wong JAJ, Hockman D, Chen C, He J, Beard MR, Eyre NS, Baumert TF, Tyrrell DL, Law JLM, Houghton M. Johnson J, et al. Among authors: tyrrell dl. J Virol. 2019 Oct 29;93(22):e00810-19. doi: 10.1128/JVI.00810-19. Print 2019 Nov 15. J Virol. 2019. PMID: 31462563 Free PMC article.

9

Progress toward approval of an HCV vaccine.

Law JL, Logan M, Landi A, Tyrrell DL, Houghton M. Law JL, et al. Among authors: tyrrell dl. Can Liver J. 2018 Oct 3;1(3):130-138. doi: 10.3138/canlivj.2018.0010. eCollection 2018 Summer. Can Liver J. 2018. PMID: 35991323 Free PMC article. Review.

10

Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism.

Sarhan MA, Abdel-Hakeem MS, Mason AL, Tyrrell DL, Houghton M. Sarhan MA, et al. Among authors: tyrrell dl. Sci Rep. 2017 May 31;7(1):2495. doi: 10.1038/s41598-017-02648-6. Sci Rep. 2017. PMID: 28566716 Free PMC article.

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