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Poxviral protein A52 stimulates p38 mitogen-activated protein kinase (MAPK) activation by causing tumor necrosis factor receptor-associated factor 6 (TRAF6) self-association leading to transforming growth factor β-activated kinase 1 (TAK1) recruitment.
Stack J, Hurst TP, Flannery SM, Brennan K, Rupp S, Oda SI, Khan AR, Bowie AG. Stack J, et al. Among authors: brennan k. J Biol Chem. 2013 Nov 22;288(47):33642-33653. doi: 10.1074/jbc.M113.485490. Epub 2013 Oct 10. J Biol Chem. 2013. PMID: 24114841 Free PMC article.
IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.
Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M. Doyle SL, et al. Among authors: brennan k. Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616. Sci Transl Med. 2014. PMID: 24695684
Btk regulates macrophage polarization in response to lipopolysaccharide.
Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA. Ní Gabhann J, et al. Among authors: brennan k. PLoS One. 2014 Jan 21;9(1):e85834. doi: 10.1371/journal.pone.0085834. eCollection 2014. PLoS One. 2014. PMID: 24465735 Free PMC article.
Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.
Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL. Mulfaul K, et al. Among authors: brennan k. Cell Rep. 2020 Feb 18;30(7):2209-2224.e5. doi: 10.1016/j.celrep.2020.01.064. Cell Rep. 2020. PMID: 32075760 Free PMC article.
Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation.
Brennan K, O'Leary BD, Mc Laughlin D, Breen EP, Connolly E, Ali N, O'Driscoll DN, Ozaki E, Mahony R, Mulfaul K, Ryan AM, Ni Chianain A, McHugh A, Molloy EJ, Hogan AE, Paran S, McAuliffe FM, Doyle SL. Brennan K, et al. J Immunol. 2018 Aug 15;201(4):1131-1143. doi: 10.4049/jimmunol.1700956. Epub 2018 Jul 6. J Immunol. 2018. PMID: 29980613
Attenuated CSF-1R signalling drives cerebrovascular pathology.
Delaney C, Farrell M, Doherty CP, Brennan K, O'Keeffe E, Greene C, Byrne K, Kelly E, Birmingham N, Hickey P, Cronin S, Savvides SN, Doyle SL, Campbell M. Delaney C, et al. Among authors: brennan k. EMBO Mol Med. 2021 Feb 5;13(2):e12889. doi: 10.15252/emmm.202012889. Epub 2020 Dec 22. EMBO Mol Med. 2021. PMID: 33350588 Free PMC article.
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