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New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564.
Frees D, Andersen JH, Hemmingsen L, Koskenniemi K, Bæk KT, Muhammed MK, Gudeta DD, Nyman TA, Sukura A, Varmanen P, Savijoki K. Frees D, et al. Among authors: baek kt. J Proteome Res. 2012 Jan 1;11(1):95-108. doi: 10.1021/pr200956s. Epub 2011 Dec 12. J Proteome Res. 2012. PMID: 22112206
Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene.
Bæk KT, Thøgersen L, Mogenssen RG, Mellergaard M, Thomsen LE, Petersen A, Skov S, Cameron DR, Peleg AY, Frees D. Bæk KT, et al. Antimicrob Agents Chemother. 2015 Nov;59(11):6983-91. doi: 10.1128/AAC.01303-15. Epub 2015 Aug 31. Antimicrob Agents Chemother. 2015. PMID: 26324273 Free PMC article.
Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus.
Villanueva M, Jousselin A, Baek KT, Prados J, Andrey DO, Renzoni A, Ingmer H, Frees D, Kelley WL. Villanueva M, et al. Among authors: baek kt. J Bacteriol. 2016 Sep 9;198(19):2719-31. doi: 10.1128/JB.00261-16. Print 2016 Oct 1. J Bacteriol. 2016. PMID: 27432833 Free PMC article.
The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis.
Jensen C, Bæk KT, Gallay C, Thalsø-Madsen I, Xu L, Jousselin A, Ruiz Torrubia F, Paulander W, Pereira AR, Veening JW, Pinho MG, Frees D. Jensen C, et al. Among authors: baek kt. PLoS Pathog. 2019 Sep 13;15(9):e1008044. doi: 10.1371/journal.ppat.1008044. eCollection 2019 Sep. PLoS Pathog. 2019. PMID: 31518377 Free PMC article.
20 results