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In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches.
Lozoya-Agullo I, Zur M, Wolk O, Beig A, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A. Lozoya-Agullo I, et al. Among authors: bermejo m. Int J Pharm. 2015 Mar 1;480(1-2):1-7. doi: 10.1016/j.ijpharm.2015.01.014. Epub 2015 Jan 13. Int J Pharm. 2015. PMID: 25595387
Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I Drug.
Colón-Useche S, González-Álvarez I, Mangas-Sanjuan V, González-Álvarez M, Pastoriza P, Molina-Martínez I, Bermejo M, García-Arieta A. Colón-Useche S, et al. Among authors: bermejo m. Mol Pharm. 2015 Sep 8;12(9):3167-74. doi: 10.1021/acs.molpharmaceut.5b00076. Epub 2015 Aug 26. Mol Pharm. 2015. PMID: 26287948
Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.
Lozoya-Agullo I, Zur M, Beig A, Fine N, Cohen Y, González-Álvarez M, Merino-Sanjuán M, González-Álvarez I, Bermejo M, Dahan A. Lozoya-Agullo I, et al. Among authors: bermejo m. Int J Pharm. 2016 Dec 30;515(1-2):201-208. doi: 10.1016/j.ijpharm.2016.09.061. Epub 2016 Sep 22. Int J Pharm. 2016. PMID: 27667756
Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.
Lozoya-Agullo I, Zur M, Fine-Shamir N, Markovic M, Cohen Y, Porat D, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A. Lozoya-Agullo I, et al. Among authors: bermejo m. Int J Pharm. 2017 Jul 15;527(1-2):135-141. doi: 10.1016/j.ijpharm.2017.05.018. Epub 2017 May 10. Int J Pharm. 2017. PMID: 28501438
Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.
Hens B, Tsume Y, Bermejo M, Paixao P, Koenigsknecht MJ, Baker JR, Hasler WL, Lionberger R, Fan J, Dickens J, Shedden K, Wen B, Wysocki J, Loebenberg R, Lee A, Frances A, Amidon G, Yu A, Benninghoff G, Salehi N, Talattof A, Sun D, Amidon GL. Hens B, et al. Among authors: bermejo m. Mol Pharm. 2017 Dec 4;14(12):4281-4294. doi: 10.1021/acs.molpharmaceut.7b00426. Epub 2017 Aug 4. Mol Pharm. 2017. PMID: 28737409 Clinical Trial.
Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.
Lozoya-Agullo I, Gonzalez-Alvarez I, Zur M, Fine-Shamir N, Cohen Y, Markovic M, Garrigues TM, Dahan A, Gonzalez-Alvarez M, Merino-Sanjuán M, Bermejo M, Avdeef A. Lozoya-Agullo I, et al. Among authors: bermejo m. Pharm Res. 2017 Dec 29;35(1):2. doi: 10.1007/s11095-017-2331-z. Pharm Res. 2017. PMID: 29288412
279 results