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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
McNeela EA, Burke A, Neill DR, Baxter C, Fernandes VE, Ferreira D, Smeaton S, El-Rachkidy R, McLoughlin RM, Mori A, Moran B, Fitzgerald KA, Tschopp J, Pétrilli V, Andrew PW, Kadioglu A, Lavelle EC. McNeela EA, et al. Among authors: lavelle ec. PLoS Pathog. 2010 Nov 11;6(11):e1001191. doi: 10.1371/journal.ppat.1001191. PLoS Pathog. 2010. PMID: 21085613 Free PMC article.
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM. Brown AF, et al. Among authors: lavelle ec. PLoS Pathog. 2015 Nov 5;11(11):e1005226. doi: 10.1371/journal.ppat.1005226. eCollection 2015. PLoS Pathog. 2015. PMID: 26539822 Free PMC article.
Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles.
Muñoz-Wolf N, Ward RW, Hearnden CH, Sharp FA, Geoghegan J, O'Grady K, McEntee CP, Shanahan KA, Guy C, Bowie AG, Campbell M, Roces CB, Anderluzzi G, Webb C, Perrie Y, Creagh E, Lavelle EC. Muñoz-Wolf N, et al. Among authors: lavelle ec. Cell Rep Med. 2023 Jan 17;4(1):100899. doi: 10.1016/j.xcrm.2022.100899. Cell Rep Med. 2023. PMID: 36652908 Free PMC article.
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
Sharp FA, Ruane D, Claass B, Creagh E, Harris J, Malyala P, Singh M, O'Hagan DT, Pétrilli V, Tschopp J, O'Neill LA, Lavelle EC. Sharp FA, et al. Among authors: lavelle ec. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):870-5. doi: 10.1073/pnas.0804897106. Epub 2009 Jan 12. Proc Natl Acad Sci U S A. 2009. PMID: 19139407 Free PMC article.
Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases.
Lüthi AU, Cullen SP, McNeela EA, Duriez PJ, Afonina IS, Sheridan C, Brumatti G, Taylor RC, Kersse K, Vandenabeele P, Lavelle EC, Martin SJ. Lüthi AU, et al. Among authors: lavelle ec. Immunity. 2009 Jul 17;31(1):84-98. doi: 10.1016/j.immuni.2009.05.007. Epub 2009 Jun 25. Immunity. 2009. PMID: 19559631 Free article.
136 results