Qiu X - Search Results

1

p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.

Ehrnhoefer DE, Skotte NH, Ladha S, Nguyen YT, Qiu X, Deng Y, Huynh KT, Engemann S, Nielsen SM, Becanovic K, Leavitt BR, Hasholt L, Hayden MR. Ehrnhoefer DE, et al. Among authors: qiu x. Hum Mol Genet. 2014 Feb 1;23(3):717-29. doi: 10.1093/hmg/ddt458. Epub 2013 Sep 18. Hum Mol Genet. 2014. PMID: 24070868

2

A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.

Aharony I, Ehrnhoefer DE, Shruster A, Qiu X, Franciosi S, Hayden MR, Offen D. Aharony I, et al. Among authors: qiu x. Hum Mol Genet. 2015 May 1;24(9):2604-14. doi: 10.1093/hmg/ddv023. Epub 2015 Jan 23. Hum Mol Genet. 2015. PMID: 25616965 Free PMC article.

3

Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.

Ehrnhoefer DE, Caron NS, Deng Y, Qiu X, Tsang M, Hayden MR. Ehrnhoefer DE, et al. Among authors: qiu x. Exp Neurol. 2016 Sep;283(Pt A):121-8. doi: 10.1016/j.expneurol.2016.06.008. Epub 2016 Jun 11. Exp Neurol. 2016. PMID: 27296315

4

Palmitoylation of caspase-6 by HIP14 regulates its activation.

Skotte NH, Sanders SS, Singaraja RR, Ehrnhoefer DE, Vaid K, Qiu X, Kannan S, Verma C, Hayden MR. Skotte NH, et al. Among authors: qiu x. Cell Death Differ. 2017 Mar;24(3):433-444. doi: 10.1038/cdd.2016.139. Epub 2016 Dec 2. Cell Death Differ. 2017. PMID: 27911442 Free PMC article.

5

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo.

Ehrnhoefer DE, Southwell AL, Sivasubramanian M, Qiu X, Villanueva EB, Xie Y, Waltl S, Anderson L, Fazeli A, Casal L, Felczak B, Tsang M, Hayden MR. Ehrnhoefer DE, et al. Among authors: qiu x. Hum Mol Genet. 2018 Jan 15;27(2):239-253. doi: 10.1093/hmg/ddx394. Hum Mol Genet. 2018. PMID: 29121340 Free PMC article.

6

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease.

Ehrnhoefer DE, Martin DDO, Schmidt ME, Qiu X, Ladha S, Caron NS, Skotte NH, Nguyen YTN, Vaid K, Southwell AL, Engemann S, Franciosi S, Hayden MR. Ehrnhoefer DE, et al. Among authors: qiu x. Acta Neuropathol Commun. 2018 Mar 6;6(1):16. doi: 10.1186/s40478-018-0518-0. Acta Neuropathol Commun. 2018. PMID: 29510748 Free PMC article.

7

Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.

Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR. Ehrnhoefer DE, et al. Among authors: qiu x. Cell Chem Biol. 2019 Sep 19;26(9):1295-1305.e6. doi: 10.1016/j.chembiol.2019.07.001. Epub 2019 Jul 25. Cell Chem Biol. 2019. PMID: 31353319 Free PMC article.

8

Compromised IGF signaling causes caspase-6 activation in Huntington disease.

Skotte NH, Pouladi MA, Ehrnhoefer DE, Huynh K, Qiu X, Nielsen SMB, Nielsen TT, Nørremølle A, Hayden MR. Skotte NH, et al. Among authors: qiu x. Exp Neurol. 2020 Oct;332:113396. doi: 10.1016/j.expneurol.2020.113396. Epub 2020 Jul 2. Exp Neurol. 2020. PMID: 32622701

9

Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.

Wong BKY, Ehrnhoefer DE, Graham RK, Martin DDO, Ladha S, Uribe V, Stanek LM, Franciosi S, Qiu X, Deng Y, Kovalik V, Zhang W, Pouladi MA, Shihabuddin LS, Hayden MR. Wong BKY, et al. Among authors: qiu x. Neurobiol Dis. 2015 Apr;76:24-36. doi: 10.1016/j.nbd.2014.12.030. Epub 2015 Jan 9. Neurobiol Dis. 2015. PMID: 25583186

10

Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.

Ladha S, Qiu X, Casal L, Caron NS, Ehrnhoefer DE, Hayden MR. Ladha S, et al. Among authors: qiu x. Cell Death Discov. 2018 Mar 12;4:40. doi: 10.1038/s41420-018-0043-8. eCollection 2018. Cell Death Discov. 2018. PMID: 29560279 Free PMC article.

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