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Overexpression of synphilin-1 promotes clearance of soluble and misfolded alpha-synuclein without restoring the motor phenotype in aged A30P transgenic mice.
Casadei N, Pöhler AM, Tomás-Zapico C, Torres-Peraza J, Schwedhelm I, Witz A, Zamolo I, De Heer R, Spruijt B, Noldus LP, Klucken J, Lucas JJ, Kahle PJ, Krüger R, Riess O, Nuber S. Casadei N, et al. Among authors: lucas jj. Hum Mol Genet. 2014 Feb 1;23(3):767-81. doi: 10.1093/hmg/ddt467. Epub 2013 Sep 24. Hum Mol Genet. 2014. PMID: 24064336
Effects of partial suppression of parkin on huntingtin mutant R6/1 mice.
Rubio I, Rodríguez-Navarro JA, Tomás-Zapico C, Ruíz C, Casarejos MJ, Perucho J, Gómez A, Rodal I, Lucas JJ, Mena MA, de Yébenes JG. Rubio I, et al. Among authors: lucas jj. Brain Res. 2009 Jul 24;1281:91-100. doi: 10.1016/j.brainres.2009.05.039. Epub 2009 May 21. Brain Res. 2009. PMID: 19464273
Presynaptic dysfunction in Huntington's disease.
Rozas JL, Gómez-Sánchez L, Tomás-Zapico C, Lucas JJ, Fernández-Chacón R. Rozas JL, et al. Among authors: lucas jj. Biochem Soc Trans. 2010 Apr;38(2):488-92. doi: 10.1042/BST0380488. Biochem Soc Trans. 2010. PMID: 20298208 Review.
The neuroprotective transcription factor ATF5 is decreased and sequestered into polyglutamine inclusions in Huntington's disease.
Hernández IH, Torres-Peraza J, Santos-Galindo M, Ramos-Morón E, Fernández-Fernández MR, Pérez-Álvarez MJ, Miranda-Vizuete A, Lucas JJ. Hernández IH, et al. Among authors: lucas jj. Acta Neuropathol. 2017 Dec;134(6):839-850. doi: 10.1007/s00401-017-1770-2. Epub 2017 Aug 31. Acta Neuropathol. 2017. PMID: 28861715 Free article.
CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington's disease.
Yu D, Zarate N, White A, Coates D, Tsai W, Nanclares C, Cuccu F, Yue JS, Brown TG, Mansky RH, Jiang K, Kim H, Nichols-Meade T, Larson SN, Gundry K, Zhang Y, Tomas-Zapico C, Lucas JJ, Benneyworth M, Öz G, Cvetanovic M, Araque A, Gomez-Pastor R. Yu D, et al. Among authors: lucas jj. Acta Neuropathol Commun. 2022 Jun 3;10(1):83. doi: 10.1186/s40478-022-01379-8. Acta Neuropathol Commun. 2022. PMID: 35659303 Free PMC article.
PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.
Saavedra A, García-Martínez JM, Xifró X, Giralt A, Torres-Peraza JF, Canals JM, Díaz-Hernández M, Lucas JJ, Alberch J, Pérez-Navarro E. Saavedra A, et al. Among authors: lucas jj. Cell Death Differ. 2010 Feb;17(2):324-35. doi: 10.1038/cdd.2009.127. Epub 2009 Sep 11. Cell Death Differ. 2010. PMID: 19745829
282 results