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Synthesis, biological evaluation, and molecular modeling of new 3-(cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) Oxime (GEBR-7b) related phosphodiesterase 4D (PDE4D) inhibitors.
Brullo C, Massa M, Rocca M, Rotolo C, Guariento S, Rivera D, Ricciarelli R, Fedele E, Fossa P, Bruno O. Brullo C, et al. Among authors: rotolo c. J Med Chem. 2014 Aug 28;57(16):7061-72. doi: 10.1021/jm500855w. Epub 2014 Aug 15. J Med Chem. 2014. PMID: 25126889
New insights into selective PDE4D inhibitors: 3-(Cyclopentyloxy)-4-methoxybenzaldehyde O-(2-(2,6-dimethylmorpholino)-2-oxoethyl) oxime (GEBR-7b) structural development and promising activities to restore memory impairment.
Brullo C, Ricciarelli R, Prickaerts J, Arancio O, Massa M, Rotolo C, Romussi A, Rebosio C, Marengo B, Pronzato MA, van Hagen BTJ, van Goethem NP, D'Ursi P, Orro A, Milanesi L, Guariento S, Cichero E, Fossa P, Fedele E, Bruno O. Brullo C, et al. Among authors: rotolo c. Eur J Med Chem. 2016 Nov 29;124:82-102. doi: 10.1016/j.ejmech.2016.08.018. Epub 2016 Aug 13. Eur J Med Chem. 2016. PMID: 27560284
Homology modeling, docking studies and molecular dynamic simulations using graphical processing unit architecture to probe the type-11 phosphodiesterase catalytic site: a computational approach for the rational design of selective inhibitors.
Cichero E, D'Ursi P, Moscatelli M, Bruno O, Orro A, Rotolo C, Milanesi L, Fossa P. Cichero E, et al. Among authors: rotolo c. Chem Biol Drug Des. 2013 Dec;82(6):718-31. doi: 10.1111/cbdd.12193. Epub 2013 Aug 26. Chem Biol Drug Des. 2013. PMID: 23865680
Ferritin Metabolism Reflects Multiple Myeloma Microenvironment and Predicts Patient Outcome.
Plano F, Gigliotta E, Corsale AM, Azgomi MS, Santonocito C, Ingrascì M, Di Carlo L, Augello AE, Speciale M, Vullo C, Rotolo C, Camarda GM, Caccamo N, Meraviglia S, Dieli F, Siragusa S, Botta C. Plano F, et al. Among authors: rotolo c. Int J Mol Sci. 2023 May 16;24(10):8852. doi: 10.3390/ijms24108852. Int J Mol Sci. 2023. PMID: 37240197 Free PMC article.
28 results