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Discovery of TP0628103: A Highly Potent and Selective MMP-7 Inhibitor with Reduced OATP-Mediated Clearance Designed by Shifting Isoelectric Points.
Oka Y, Abe-Sato K, Tabuse H, Yasukawa Y, Yahara T, Nishimoto T, Kamitani M, Fukunaga T, Ochiai N, Kumasaka-Abe T, Hitaka K, Gunji E, Ohara H, Takeda T, Kojima N, Asami T. Oka Y, et al. Among authors: kamitani m. J Med Chem. 2024 Jan 25;67(2):1406-1420. doi: 10.1021/acs.jmedchem.3c01967. Epub 2024 Jan 12. J Med Chem. 2024. PMID: 38214909
Discovery of novel indole derivatives as potent and selective inhibitors of proMMP-9 activation.
Nishikawa-Shimono R, Kuwabara M, Fujisaki S, Matsuda D, Endo M, Kamitani M, Futamura A, Nomura Y, Yamaguchi-Sasaki T, Yabuuchi T, Yamaguchi C, Tanaka-Yamamoto N, Satake S, Abe-Sato K, Funayama K, Sakata M, Takahashi S, Hirano K, Fukunaga T, Uozumi Y, Kato S, Tamura Y, Nakamori T, Mima M, Mishima-Tsumagari C, Nozawa D, Imai Y, Asami T. Nishikawa-Shimono R, et al. Among authors: kamitani m. Bioorg Med Chem Lett. 2024 Jan 1;97:129541. doi: 10.1016/j.bmcl.2023.129541. Epub 2023 Nov 10. Bioorg Med Chem Lett. 2024. PMID: 37952596
Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold.
Takeuchi T, Nomura Y, Tamita T, Nishikawa R, Kakinuma H, Kojima N, Hitaka K, Tamura Y, Kamitani M, Mima M, Nozoe A, Hayashi M. Takeuchi T, et al. Among authors: kamitani m. J Med Chem. 2023 Jan 12;66(1):822-836. doi: 10.1021/acs.jmedchem.2c01698. Epub 2023 Jan 3. J Med Chem. 2023. PMID: 36595440
DeLTa-Seq: direct-lysate targeted RNA-Seq from crude tissue lysate.
Kashima M, Kamitani M, Nomura Y, Mori-Moriyama N, Betsuyaku S, Hirata H, Nagano AJ. Kashima M, et al. Among authors: kamitani m. Plant Methods. 2022 Aug 6;18(1):99. doi: 10.1186/s13007-022-00930-x. Plant Methods. 2022. PMID: 35933383 Free PMC article.
Discovery of Aryloxyphenyl-Heptapeptide Hybrids as Potent and Selective Matrix Metalloproteinase-2 Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis.
Takeuchi T, Hayashi M, Tamita T, Nomura Y, Kojima N, Mitani A, Takeda T, Hitaka K, Kato Y, Kamitani M, Mima M, Toki H, Ohkubo M, Nozoe A, Kakinuma H. Takeuchi T, et al. Among authors: kamitani m. J Med Chem. 2022 Jun 23;65(12):8493-8510. doi: 10.1021/acs.jmedchem.2c00613. Epub 2022 Jun 10. J Med Chem. 2022. PMID: 35687819
53 results