Horne G - Search Results

1

Synthesis of eight stereoisomers of pochonicine: nanomolar inhibition of β-N-acetylhexosaminidases.

Zhu JS, Nakagawa S, Chen W, Adachi I, Jia YM, Hu XG, Fleet GW, Wilson FX, Nitoda T, Horne G, van Well R, Kato A, Yu CY. Zhu JS, et al. Among authors: horne g. J Org Chem. 2013 Oct 18;78(20):10298-309. doi: 10.1021/jo401694e. Epub 2013 Sep 30. J Org Chem. 2013. PMID: 24032658

2

Synthesis of fully substituted polyhydroxylated pyrrolizidines via Cope-House cyclization.

Zhang W, Sato K, Kato A, Jia YM, Hu XG, Wilson FX, van Well R, Horne G, Fleet GW, Nash RJ, Yu CY. Zhang W, et al. Among authors: horne g. Org Lett. 2011 Aug 19;13(16):4414-7. doi: 10.1021/ol201749c. Epub 2011 Jul 28. Org Lett. 2011. PMID: 21797200

3

General synthesis of sugar-derived azepane nitrones: precursors of azepane iminosugars.

Zhao WB, Nakagawa S, Kato A, Adachi I, Jia YM, Hu XG, Fleet GW, Wilson FX, Horne G, Yoshihara A, Izumori K, Yu CY. Zhao WB, et al. Among authors: horne g. J Org Chem. 2013 Apr 5;78(7):3208-21. doi: 10.1021/jo400130p. Epub 2013 Mar 11. J Org Chem. 2013. PMID: 23458237

4

Therapeutic applications of iminosugars: current perspectives and future opportunities.

Horne G, Wilson FX. Horne G, et al. Prog Med Chem. 2011;50:135-76. doi: 10.1016/B978-0-12-381290-2.00004-5. Prog Med Chem. 2011. PMID: 21315930 No abstract available.

5

Iminosugars past, present and future: medicines for tomorrow.

Horne G, Wilson FX, Tinsley J, Williams DH, Storer R. Horne G, et al. Drug Discov Today. 2011 Feb;16(3-4):107-18. doi: 10.1016/j.drudis.2010.08.017. Epub 2010 Sep 21. Drug Discov Today. 2011. PMID: 20817006 Review.

6

Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies.

Mellone M, Kestoras D, Andrews MR, Dassie E, Crowther RA, Stokin GB, Tinsley J, Horne G, Goedert M, Tolkovsky AM, Spillantini MG. Mellone M, et al. Among authors: horne g. J Neurosci. 2013 Nov 13;33(46):18175-89. doi: 10.1523/JNEUROSCI.4933-12.2013. J Neurosci. 2013. PMID: 24227726 Free PMC article.

7

Synthesis of the enantiomers of 6-deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, structural analogues of myo-inositol 1,3,4,5-tetrakisphosphate.

Horne G, Potter BV. Horne G, et al. Chemistry. 2001 Jan 5;7(1):80-7. doi: 10.1002/1521-3765(20010105)7:1<80::aid-chem80>3.0.co;2-b. Chemistry. 2001. PMID: 11205029

8

First derivatives of myo-inositol 1,4,6-trisphosphate modified at positions 2 and 3: structural analogues of D-myo-inositol 1,4,5-trisphosphate.

Horne G, Mills SJ, Potter BV. Horne G, et al. Carbohydr Res. 2004 Jan 2;339(1):51-65. doi: 10.1016/j.carres.2003.09.008. Carbohydr Res. 2004. PMID: 14659671

9

D-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: biological activity and pH-dependent conformational properties.

Horne G, Maechling C, Fleig A, Hirata M, Penner R, Spiess B, Potter BV. Horne G, et al. Biochem Biophys Res Commun. 2004 Aug 6;320(4):1262-70. doi: 10.1016/j.bbrc.2004.06.079. Biochem Biophys Res Commun. 2004. PMID: 15249226

10

Total synthesis of nucleobase-modified adenophostin A mimics.

Shuto S, Horne G, Marwood RD, Potter BV. Shuto S, et al. Among authors: horne g. Chemistry. 2001 Nov 19;7(22):4937-46. doi: 10.1002/1521-3765(20011119)7:22<4937::aid-chem4937>3.0.co;2-g. Chemistry. 2001. PMID: 11763462

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