Saibil HR - Search Results

1

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Nicoll AJ, et al. Among authors: saibil hr. Nat Commun. 2013;4:2416. doi: 10.1038/ncomms3416. Nat Commun. 2013. PMID: 24022506 Free PMC article.

2

Reversible conversion of monomeric human prion protein between native and fibrilogenic conformations.

Jackson GS, Hosszu LL, Power A, Hill AF, Kenney J, Saibil H, Craven CJ, Waltho JP, Clarke AR, Collinge J. Jackson GS, et al. Science. 1999 Mar 19;283(5409):1935-7. doi: 10.1126/science.283.5409.1935. Science. 1999. PMID: 10082469

3

Elongated oligomers assemble into mammalian PrP amyloid fibrils.

Tattum MH, Cohen-Krausz S, Thumanu K, Wharton CW, Khalili-Shirazi A, Jackson GS, Orlova EV, Collinge J, Clarke AR, Saibil HR. Tattum MH, et al. Among authors: saibil hr. J Mol Biol. 2006 Mar 31;357(3):975-85. doi: 10.1016/j.jmb.2006.01.052. Epub 2006 Jan 31. J Mol Biol. 2006. PMID: 16473369

4

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites.

Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Freir DB, et al. Among authors: saibil hr. Nat Commun. 2011 Jun 7;2:336. doi: 10.1038/ncomms1341. Nat Commun. 2011. PMID: 21654636 Free PMC article.

5

N-terminal domain of prion protein directs its oligomeric association.

Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR. Trevitt CR, et al. Among authors: saibil hr. J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074940 Free PMC article.

6

A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.

Wenborn A, Terry C, Gros N, Joiner S, D'Castro L, Panico S, Sells J, Cronier S, Linehan JM, Brandner S, Saibil HR, Collinge J, Wadsworth JD. Wenborn A, et al. Among authors: saibil hr. Sci Rep. 2015 May 7;5:10062. doi: 10.1038/srep10062. Sci Rep. 2015. PMID: 25950908 Free PMC article.

7

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils.

Terry C, Wenborn A, Gros N, Sells J, Joiner S, Hosszu LL, Tattum MH, Panico S, Clare DK, Collinge J, Saibil HR, Wadsworth JD. Terry C, et al. Among authors: saibil hr. Open Biol. 2016 May;6(5):160035. doi: 10.1098/rsob.160035. Epub 2016 May 4. Open Biol. 2016. PMID: 27249641 Free PMC article.

8

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro.

Terry C, Harniman RL, Sells J, Wenborn A, Joiner S, Saibil HR, Miles MJ, Collinge J, Wadsworth JDF. Terry C, et al. Among authors: saibil hr. Sci Rep. 2019 Jan 23;9(1):376. doi: 10.1038/s41598-018-36700-w. Sci Rep. 2019. PMID: 30675000 Free PMC article.

9

2.7 Å cryo-EM structure of ex vivo RML prion fibrils.

Manka SW, Zhang W, Wenborn A, Betts J, Joiner S, Saibil HR, Collinge J, Wadsworth JDF. Manka SW, et al. Among authors: saibil hr. Nat Commun. 2022 Jul 13;13(1):4004. doi: 10.1038/s41467-022-30457-7. Nat Commun. 2022. PMID: 35831275 Free PMC article.

10

A structural basis for prion strain diversity.

Manka SW, Wenborn A, Betts J, Joiner S, Saibil HR, Collinge J, Wadsworth JDF. Manka SW, et al. Among authors: saibil hr. Nat Chem Biol. 2023 May;19(5):607-613. doi: 10.1038/s41589-022-01229-7. Epub 2023 Jan 16. Nat Chem Biol. 2023. PMID: 36646960 Free PMC article.

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