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Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development.
Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, Moore R, Gugiu G, Lee TD, Yip R, Chen Y, Jove R, Horne D, Williams JC. Buettner R, et al. Among authors: yuan yc. ACS Chem Biol. 2011 May 20;6(5):432-43. doi: 10.1021/cb100253e. Epub 2011 Feb 16. ACS Chem Biol. 2011. PMID: 21226522 Free PMC article.
Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.
Nam S, Wen W, Schroeder A, Herrmann A, Yu H, Cheng X, Merz KH, Eisenbrand G, Li H, Yuan YC, Jove R. Nam S, et al. Among authors: yuan yc. Mol Oncol. 2013 Jun;7(3):369-78. doi: 10.1016/j.molonc.2012.10.013. Epub 2012 Nov 16. Mol Oncol. 2013. PMID: 23206899 Free PMC article.
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro.
Chen MC, Zhou B, Zhang K, Yuan YC, Un F, Hu S, Chou CM, Chen CH, Wu J, Wang Y, Liu X, Smith DL, Li H, Liu Z, Warden CD, Su L, Malkas LH, Chung YM, Hu MC, Yen Y. Chen MC, et al. Among authors: yuan yc. Mol Pharmacol. 2015 Jun;87(6):996-1005. doi: 10.1124/mol.114.094987. Epub 2015 Mar 26. Mol Pharmacol. 2015. PMID: 25814515 Free PMC article.
Multi-Kinase Inhibitor with Anti-p38γ Activity in Cutaneous T-Cell Lymphoma.
Zhang XH, Nam S, Wu J, Chen CH, Liu X, Li H, McKeithan T, Gong Q, Chan WC, Yin HH, Yuan YC, Pillai R, Querfeld C, Horne D, Chen Y, Rosen ST. Zhang XH, et al. Among authors: yuan yc. J Invest Dermatol. 2018 Nov;138(11):2377-2387. doi: 10.1016/j.jid.2018.04.030. Epub 2018 Jul 14. J Invest Dermatol. 2018. PMID: 29758280 Free PMC article.
The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA.
Gu L, Lingeman R, Yakushijin F, Sun E, Cui Q, Chao J, Hu W, Li H, Hickey RJ, Stark JM, Yuan YC, Chen Y, Vonderfecht SL, Synold TW, Shi Y, Reckamp KL, Horne D, Malkas LH. Gu L, et al. Among authors: yuan yc. Clin Cancer Res. 2018 Dec 1;24(23):6053-6065. doi: 10.1158/1078-0432.CCR-18-0592. Epub 2018 Jul 2. Clin Cancer Res. 2018. PMID: 29967249 Free PMC article.
Molecular characterization of aromatase.
Hong Y, Li H, Yuan YC, Chen S. Hong Y, et al. Among authors: yuan yc. Ann N Y Acad Sci. 2009 Feb;1155:112-20. doi: 10.1111/j.1749-6632.2009.03703.x. Ann N Y Acad Sci. 2009. PMID: 19250198 Free PMC article. Review.
175 results