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MYO5B, STX3, and STXBP2 mutations reveal a common disease mechanism that unifies a subset of congenital diarrheal disorders: A mutation update.
Dhekne HS, Pylypenko O, Overeem AW, Zibouche M, Ferreira RJ, van der Velde KJ, Rings EHHM, Posovszky C, van der Sluijs P, Swertz MA, Houdusse A, van IJzendoorn SCD. Dhekne HS, et al. Among authors: houdusse a. Hum Mutat. 2018 Mar;39(3):333-344. doi: 10.1002/humu.23386. Epub 2018 Jan 17. Hum Mutat. 2018. PMID: 29266534 Free PMC article. Review.
Myosin MyTH4-FERM structures highlight important principles of convergent evolution.
Planelles-Herrero VJ, Blanc F, Sirigu S, Sirkia H, Clause J, Sourigues Y, Johnsrud DO, Amigues B, Cecchini M, Gilbert SP, Houdusse A, Titus MA. Planelles-Herrero VJ, et al. Among authors: houdusse a. Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2906-15. doi: 10.1073/pnas.1600736113. Epub 2016 May 10. Proc Natl Acad Sci U S A. 2016. PMID: 27166421 Free PMC article.
Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Sirigu S, Hartman JJ, Planelles-Herrero VJ, Ropars V, Clancy S, Wang X, Chuang G, Qian X, Lu PP, Barrett E, Rudolph K, Royer C, Morgan BP, Stura EA, Malik FI, Houdusse AM. Sirigu S, et al. Among authors: houdusse am. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7448-E7455. doi: 10.1073/pnas.1609342113. Epub 2016 Nov 4. Proc Natl Acad Sci U S A. 2016. PMID: 27815532 Free PMC article.
How actin initiates the motor activity of Myosin.
Llinas P, Isabet T, Song L, Ropars V, Zong B, Benisty H, Sirigu S, Morris C, Kikuti C, Safer D, Sweeney HL, Houdusse A. Llinas P, et al. Among authors: houdusse a. Dev Cell. 2015 May 26;33(4):401-12. doi: 10.1016/j.devcel.2015.03.025. Epub 2015 Apr 30. Dev Cell. 2015. PMID: 25936506 Free PMC article.
Force-producing ADP state of myosin bound to actin.
Wulf SF, Ropars V, Fujita-Becker S, Oster M, Hofhaus G, Trabuco LG, Pylypenko O, Sweeney HL, Houdusse AM, Schröder RR. Wulf SF, et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1844-52. doi: 10.1073/pnas.1516598113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976594 Free PMC article.
The myosin X motor is optimized for movement on actin bundles.
Ropars V, Yang Z, Isabet T, Blanc F, Zhou K, Lin T, Liu X, Hissier P, Samazan F, Amigues B, Yang ED, Park H, Pylypenko O, Cecchini M, Sindelar CV, Sweeney HL, Houdusse A. Ropars V, et al. Among authors: houdusse a. Nat Commun. 2016 Sep 1;7:12456. doi: 10.1038/ncomms12456. Nat Commun. 2016. PMID: 27580874 Free PMC article.
107 results