Keller TH - Search Results

1

Drug design for flavivirus proteases: what are we missing?

Poulsen A, Kang C, Keller TH. Poulsen A, et al. Among authors: keller th. Curr Pharm Des. 2014;20(21):3422-7. doi: 10.2174/13816128113199990633. Curr Pharm Des. 2014. PMID: 24001226 Review.

2

Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR.

Kang C, Gayen S, Wang W, Severin R, Chen AS, Lim HA, Chia CS, Schüller A, Doan DN, Poulsen A, Hill J, Vasudevan SG, Keller TH. Kang C, et al. Among authors: keller th. Antiviral Res. 2013 Feb;97(2):137-44. doi: 10.1016/j.antiviral.2012.11.008. Epub 2012 Dec 2. Antiviral Res. 2013. PMID: 23211132

3

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.

Kim YM, Gayen S, Kang C, Joy J, Huang Q, Chen AS, Wee JL, Ang MJ, Lim HA, Hung AW, Li R, Noble CG, Lee le T, Yip A, Wang QY, Chia CS, Hill J, Shi PY, Keller TH. Kim YM, et al. Among authors: keller th. J Biol Chem. 2013 May 3;288(18):12891-900. doi: 10.1074/jbc.M112.442723. Epub 2013 Mar 19. J Biol Chem. 2013. PMID: 23511634 Free PMC article.

4

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.

Ang MJ, Lau QY, Ng FM, Then SW, Poulsen A, Cheong YK, Ngoh ZX, Tan YW, Peng J, Keller TH, Hill J, Chu JJ, Chia CS. Ang MJ, et al. Among authors: keller th. J Enzyme Inhib Med Chem. 2016;31(2):332-9. doi: 10.3109/14756366.2015.1018245. Epub 2015 Sep 4. J Enzyme Inhib Med Chem. 2016. PMID: 25792507

5

Pharmacophore Model for Wnt/Porcupine Inhibitors and Its Use in Drug Design.

Poulsen A, Ho SY, Wang W, Alam J, Jeyaraj DA, Ang SH, Tan ES, Lin GR, Cheong VW, Ke Z, Lee MA, Keller TH. Poulsen A, et al. Among authors: keller th. J Chem Inf Model. 2015 Jul 27;55(7):1435-48. doi: 10.1021/acs.jcim.5b00159. Epub 2015 Jun 15. J Chem Inf Model. 2015. PMID: 26024410

6

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Li Y, Zhang Z, Phoo WW, Loh YR, Wang W, Liu S, Chen MW, Hung AW, Keller TH, Luo D, Kang C. Li Y, et al. Among authors: keller th. Structure. 2017 Aug 1;25(8):1242-1250.e3. doi: 10.1016/j.str.2017.06.006. Epub 2017 Jul 6. Structure. 2017. PMID: 28689970 Free article.

7

Zika Virus Protease: An Antiviral Drug Target.

Kang C, Keller TH, Luo D. Kang C, et al. Among authors: keller th. Trends Microbiol. 2017 Oct;25(10):797-808. doi: 10.1016/j.tim.2017.07.001. Epub 2017 Aug 5. Trends Microbiol. 2017. PMID: 28789826 Review.

8

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Li Y, Zhang Z, Phoo WW, Loh YR, Li R, Yang HY, Jansson AE, Hill J, Keller TH, Nacro K, Luo D, Kang C. Li Y, et al. Among authors: keller th. Structure. 2018 Apr 3;26(4):555-564.e3. doi: 10.1016/j.str.2018.02.005. Epub 2018 Mar 8. Structure. 2018. PMID: 29526431 Free article.

9

Probing biological mechanisms with chemical tools.

Kang C, Keller TH. Kang C, et al. Among authors: keller th. Pharmacol Res. 2020 Mar;153:104656. doi: 10.1016/j.phrs.2020.104656. Epub 2020 Jan 18. Pharmacol Res. 2020. PMID: 31962154 Review.

10

Application of Fragment-Based Drug Discovery against DNA Gyrase B.

Chen GY, Ng FM, Tan YW, Poulsen A, Seetoh W, Lin G, Kang C, Then SW, Ahmad NH, Wong YL, Ng HQ, Chia CSB, Lau QY, Hill J, Hung AW, Keller TH. Chen GY, et al. Among authors: keller th. Chempluschem. 2015 Aug;80(8):1250-1254. doi: 10.1002/cplu.201500197. Epub 2015 Jun 24. Chempluschem. 2015. PMID: 31973307

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