Kelley RF - Search Results

1

Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibody-dependent cellular cytotoxicity.

Shatz W, Chung S, Li B, Marshall B, Tejada M, Phung W, Sandoval W, Kelley RF, Scheer JM. Shatz W, et al. Among authors: kelley rf. MAbs. 2013 Nov-Dec;5(6):872-81. doi: 10.4161/mabs.26307. Epub 2013 Aug 29. MAbs. 2013. PMID: 23995614 Free PMC article.

2

Improving therapeutic efficacy of a complement receptor by structure-based affinity maturation.

Li B, Xi H, Diehl L, Lee WP, Sturgeon L, Chinn J, Deforge L, Kelley RF, Wiesmann C, van Lookeren Campagne M, Sidhu SS. Li B, et al. Among authors: kelley rf. J Biol Chem. 2009 Dec 18;284(51):35605-11. doi: 10.1074/jbc.M109.035170. J Biol Chem. 2009. PMID: 19833734 Free PMC article.

3

Superior in vivo efficacy of afucosylated trastuzumab in the treatment of HER2-amplified breast cancer.

Junttila TT, Parsons K, Olsson C, Lu Y, Xin Y, Theriault J, Crocker L, Pabonan O, Baginski T, Meng G, Totpal K, Kelley RF, Sliwkowski MX. Junttila TT, et al. Among authors: kelley rf. Cancer Res. 2010 Jun 1;70(11):4481-9. doi: 10.1158/0008-5472.CAN-09-3704. Epub 2010 May 18. Cancer Res. 2010. PMID: 20484044

4

Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG.

Wang X, Quarmby V, Ng C, Chuntharapai A, Shek T, Eigenbrot C, Kelley RF, Shia S, McCutcheon K, Lowe J, Leddy C, Coachman K, Cain G, Chu F, Hotzel I, Maia M, Wakshull E, Yang J. Wang X, et al. Among authors: kelley rf. MAbs. 2013 Jul-Aug;5(4):540-54. doi: 10.4161/mabs.24822. Epub 2013 Apr 29. MAbs. 2013. PMID: 23774668 Free PMC article.

5

A strategy for risk mitigation of antibodies with fast clearance.

Hötzel I, Theil FP, Bernstein LJ, Prabhu S, Deng R, Quintana L, Lutman J, Sibia R, Chan P, Bumbaca D, Fielder P, Carter PJ, Kelley RF. Hötzel I, et al. Among authors: kelley rf. MAbs. 2012 Nov-Dec;4(6):753-60. doi: 10.4161/mabs.22189. MAbs. 2012. PMID: 23778268 Free PMC article.

6

Development and preclinical characterization of a humanized antibody targeting CXCL12.

Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. Zhong C, et al. Among authors: kelley rf. Clin Cancer Res. 2013 Aug 15;19(16):4433-45. doi: 10.1158/1078-0432.CCR-13-0943. Epub 2013 Jun 28. Clin Cancer Res. 2013. PMID: 23812669

7

In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation.

Li B, Fouts AE, Stengel K, Luan P, Dillon M, Liang WC, Feierbach B, Kelley RF, Hötzel I. Li B, et al. Among authors: kelley rf. MAbs. 2014 Mar-Apr;6(2):437-45. doi: 10.4161/mabs.27875. Epub 2014 Jan 16. MAbs. 2014. PMID: 24492299 Free PMC article.

8

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys.

Leabman MK, Meng YG, Kelley RF, DeForge LE, Cowan KJ, Iyer S. Leabman MK, et al. Among authors: kelley rf. MAbs. 2013 Nov-Dec;5(6):896-903. doi: 10.4161/mabs.26436. MAbs. 2013. PMID: 24492343 Free PMC article.

9

Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge.

Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Li B, et al. Among authors: kelley rf. MAbs. 2014;6(5):1255-64. doi: 10.4161/mabs.29809. Epub 2014 Oct 30. MAbs. 2014. PMID: 25517310 Free PMC article.

10

Increased in vivo effector function of human IgG4 isotype antibodies through afucosylation.

Gong Q, Hazen M, Marshall B, Crowell SR, Ou Q, Wong AW, Phung W, Vernes JM, Meng YG, Tejada M, Andersen D, Kelley RF. Gong Q, et al. Among authors: kelley rf. MAbs. 2016 Aug-Sep;8(6):1098-106. doi: 10.1080/19420862.2016.1189049. Epub 2016 May 24. MAbs. 2016. PMID: 27216702 Free PMC article.

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