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N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.
Gregory KJ, Herman EJ, Ramsey AJ, Hammond AS, Byun NE, Stauffer SR, Manka JT, Jadhav S, Bridges TM, Weaver CD, Niswender CM, Steckler T, Drinkenburg WH, Ahnaou A, Lavreysen H, Macdonald GJ, Bartolomé JM, Mackie C, Hrupka BJ, Caron MG, Daigle TL, Lindsley CW, Conn PJ, Jones CK. Gregory KJ, et al. Among authors: ramsey aj. J Pharmacol Exp Ther. 2013 Nov;347(2):438-57. doi: 10.1124/jpet.113.206623. Epub 2013 Aug 21. J Pharmacol Exp Ther. 2013. PMID: 23965381 Free PMC article.
Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter.
Salahpour A, Ramsey AJ, Medvedev IO, Kile B, Sotnikova TD, Holmstrand E, Ghisi V, Nicholls PJ, Wong L, Murphy K, Sesack SR, Wightman RM, Gainetdinov RR, Caron MG. Salahpour A, et al. Among authors: ramsey aj. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4405-10. doi: 10.1073/pnas.0707646105. Epub 2008 Mar 17. Proc Natl Acad Sci U S A. 2008. PMID: 18347339 Free PMC article.
Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.
Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR. Barak LS, et al. Among authors: ramsey aj. Mol Pharmacol. 2008 Sep;74(3):585-594. doi: 10.1124/mol.108.048884. Epub 2008 Jun 4. Mol Pharmacol. 2008. PMID: 18524885 Free PMC article.
Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.
Dzirasa K, Ramsey AJ, Takahashi DY, Stapleton J, Potes JM, Williams JK, Gainetdinov RR, Sameshima K, Caron MG, Nicolelis MA. Dzirasa K, et al. Among authors: ramsey aj. J Neurosci. 2009 Jun 24;29(25):8215-24. doi: 10.1523/JNEUROSCI.1773-09.2009. J Neurosci. 2009. PMID: 19553461 Free PMC article.
Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.
Grannan MD, Mielnik CA, Moran SP, Gould RW, Ball J, Lu Z, Bubser M, Ramsey AJ, Abe M, Cho HP, Nance KD, Blobaum AL, Niswender CM, Conn PJ, Lindsley CW, Jones CK. Grannan MD, et al. Among authors: ramsey aj. ACS Chem Neurosci. 2016 Dec 21;7(12):1706-1716. doi: 10.1021/acschemneuro.6b00230. Epub 2016 Oct 5. ACS Chem Neurosci. 2016. PMID: 27617634 Free PMC article.
78 results