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Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
Yang H, Yang T, Baur JA, Perez E, Matsui T, Carmona JJ, Lamming DW, Souza-Pinto NC, Bohr VA, Rosenzweig A, de Cabo R, Sauve AA, Sinclair DA. Yang H, et al. Among authors: baur ja. Cell. 2007 Sep 21;130(6):1095-107. doi: 10.1016/j.cell.2007.07.035. Cell. 2007. PMID: 17889652 Free PMC article.
Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice.
Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Miller RA, et al. Among authors: baur ja. J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201. doi: 10.1093/gerona/glq178. Epub 2010 Oct 25. J Gerontol A Biol Sci Med Sci. 2011. PMID: 20974732 Free PMC article.
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. Price NL, et al. Among authors: baur ja. Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003. Cell Metab. 2012. PMID: 22560220 Free PMC article.
Rapalogs and mTOR inhibitors as anti-aging therapeutics.
Lamming DW, Ye L, Sabatini DM, Baur JA. Lamming DW, et al. Among authors: baur ja. J Clin Invest. 2013 Mar;123(3):980-9. doi: 10.1172/JCI64099. Epub 2013 Mar 1. J Clin Invest. 2013. PMID: 23454761 Free PMC article. Review.
mTOR: more targets of resveratrol?
Widlund AL, Baur JA, Vang O. Widlund AL, et al. Among authors: baur ja. Expert Rev Mol Med. 2013 Sep 23;15:e10. doi: 10.1017/erm.2013.11. Expert Rev Mol Med. 2013. PMID: 24060150 Review.
140 results