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Improving biophysical properties of a bispecific antibody scaffold to aid developability: quality by molecular design.
Von Kreudenstein TS, Escobar-Carbrera E, Lario PI, D'Angelo I, Brault K, Kelly J, Durocher Y, Baardsnes J, Woods RJ, Xie MH, Girod PA, Suits MD, Boulanger MJ, Poon DK, Ng GY, Dixit SB. Von Kreudenstein TS, et al. Among authors: boulanger mj. MAbs. 2013 Sep-Oct;5(5):646-54. doi: 10.4161/mabs.25632. Epub 2013 Jul 8. MAbs. 2013. PMID: 23924797 Free PMC article.
Monoclonal antibody 7H2.2 binds the C-terminus of the cancer-oocyte antigen SAS1B through the hydrophilic face of a conserved amphipathic helix corresponding to one of only two regions predicted to be ordered.
Legg MSG, Gagnon SML, Powell CJ, Boulanger MJ, Li AJJ, Evans SV. Legg MSG, et al. Among authors: boulanger mj. Acta Crystallogr D Struct Biol. 2022 May 1;78(Pt 5):623-632. doi: 10.1107/S2059798322003011. Epub 2022 Apr 20. Acta Crystallogr D Struct Biol. 2022. PMID: 35503210
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