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Conditionals by inversion provide a universal method for the generation of conditional alleles.
Economides AN, Frendewey D, Yang P, Dominguez MG, Dore AT, Lobov IB, Persaud T, Rojas J, McClain J, Lengyel P, Droguett G, Chernomorsky R, Stevens S, Auerbach W, Dechiara TM, Pouyemirou W, Cruz JM Jr, Feeley K, Mellis IA, Yasenchack J, Hatsell SJ, Xie L, Latres E, Huang L, Zhang Y, Pefanis E, Skokos D, Deckelbaum RA, Croll SD, Davis S, Valenzuela DM, Gale NW, Murphy AJ, Yancopoulos GD. Economides AN, et al. Among authors: chernomorsky r. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3179-88. doi: 10.1073/pnas.1217812110. Epub 2013 Aug 5. Proc Natl Acad Sci U S A. 2013. PMID: 23918385 Free PMC article.
High-throughput engineering of the mouse genome coupled with high-resolution expression analysis.
Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC, Rojas J, Yasenchak J, Chernomorsky R, Boucher M, Elsasser AL, Esau L, Zheng J, Griffiths JA, Wang X, Su H, Xue Y, Dominguez MG, Noguera I, Torres R, Macdonald LE, Stewart AF, DeChiara TM, Yancopoulos GD. Valenzuela DM, et al. Among authors: chernomorsky r. Nat Biotechnol. 2003 Jun;21(6):652-9. doi: 10.1038/nbt822. Epub 2003 May 5. Nat Biotechnol. 2003. PMID: 12730667
The loss-of-allele assay for ES cell screening and mouse genotyping.
Frendewey D, Chernomorsky R, Esau L, Om J, Xue Y, Murphy AJ, Yancopoulos GD, Valenzuela DM. Frendewey D, et al. Among authors: chernomorsky r. Methods Enzymol. 2010;476:295-307. doi: 10.1016/S0076-6879(10)76017-1. Methods Enzymol. 2010. PMID: 20691873
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.
Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, Schoenherr CJ, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides AN. Hatsell SJ, et al. Among authors: chernomorsky r. Sci Transl Med. 2015 Sep 2;7(303):303ra137. doi: 10.1126/scitranslmed.aac4358. Sci Transl Med. 2015. PMID: 26333933 Free PMC article.