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Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response.
Uribe-Herranz M, Rafail S, Beghi S, Gil-de-Gómez L, Verginadis I, Bittinger K, Pustylnikov S, Pierini S, Perales-Linares R, Blair IA, Mesaros CA, Snyder NW, Bushman F, Koumenis C, Facciabene A. Uribe-Herranz M, et al. Among authors: perales linares r. J Clin Invest. 2020 Jan 2;130(1):466-479. doi: 10.1172/JCI124332. J Clin Invest. 2020. PMID: 31815742 Free PMC article.
Trial watch: DNA-based vaccines for oncological indications.
Pierini S, Perales-Linares R, Uribe-Herranz M, Pol JG, Zitvogel L, Kroemer G, Facciabene A, Galluzzi L. Pierini S, et al. Among authors: perales linares r. Oncoimmunology. 2017 Nov 20;6(12):e1398878. doi: 10.1080/2162402X.2017.1398878. eCollection 2017. Oncoimmunology. 2017. PMID: 29209575 Free PMC article. Review.
Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression.
Pierini S, Mishra A, Perales-Linares R, Uribe-Herranz M, Beghi S, Giglio A, Pustylnikov S, Costabile F, Rafail S, Amici A, Facciponte JG, Koumenis C, Facciabene A. Pierini S, et al. Among authors: perales linares r. J Immunother Cancer. 2021 Feb;9(2):e001636. doi: 10.1136/jitc-2020-001636. J Immunother Cancer. 2021. PMID: 33563772 Free PMC article.
Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance.
Perales-Linares R, Leli NM, Mohei H, Beghi S, Rivera OD, Kostopoulos N, Giglio A, George SS, Uribe-Herranz M, Costabile F, Pierini S, Pustylnikov S, Skoufos G, Barash Y, Hatzigeorgiou AG, Koumenis C, Maity A, Lotze MT, Facciabene A. Perales-Linares R, et al. Cancer Res. 2023 Nov 1;83(21):3562-3576. doi: 10.1158/0008-5472.CAN-22-2499. Cancer Res. 2023. PMID: 37578274 Free PMC article.
Personalized neoantigen vaccine and pembrolizumab in advanced hepatocellular carcinoma: a phase 1/2 trial.
Yarchoan M, Gane EJ, Marron TU, Perales-Linares R, Yan J, Cooch N, Shu DH, Fertig EJ, Kagohara LT, Bartha G, Northcott J, Lyle J, Rochestie S, Peters J, Connor JT, Jaffee EM, Csiki I, Weiner DB, Perales-Puchalt A, Sardesai NY. Yarchoan M, et al. Among authors: perales linares r. Nat Med. 2024 Apr;30(4):1044-1053. doi: 10.1038/s41591-024-02894-y. Epub 2024 Apr 7. Nat Med. 2024. PMID: 38584166 Free PMC article. Clinical Trial.