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The dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 exerts anti-diabetic effects in db/db mice without peroxisome proliferator-activated receptor gamma-associated adverse cardiac effects.
Hanf R, Millatt LJ, Cariou B, Noel B, Rigou G, Delataille P, Daix V, Hum DW, Staels B. Hanf R, et al. Among authors: hum dw. Diab Vasc Dis Res. 2014 Nov;11(6):440-7. doi: 10.1177/1479164114548027. Epub 2014 Sep 11. Diab Vasc Dis Res. 2014. PMID: 25212694 Free article.
Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.
Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ, Baron M, Lucas A, Tailleux A, Hum DW, Ratziu V, Cariou B, Hanf R. Staels B, et al. Among authors: hum dw. Hepatology. 2013 Dec;58(6):1941-52. doi: 10.1002/hep.26461. Epub 2013 Oct 29. Hepatology. 2013. PMID: 23703580 Clinical Trial.
Safety issues and prospects for future generations of PPAR modulators.
Rubenstrunk A, Hanf R, Hum DW, Fruchart JC, Staels B. Rubenstrunk A, et al. Among authors: hum dw. Biochim Biophys Acta. 2007 Aug;1771(8):1065-81. doi: 10.1016/j.bbalip.2007.02.003. Epub 2007 Feb 24. Biochim Biophys Acta. 2007. PMID: 17428730 Review.
Farnesoid X receptor represses hepatic lipase gene expression.
Sirvent A, Verhoeven AJ, Jansen H, Kosykh V, Darteil RJ, Hum DW, Fruchart JC, Staels B. Sirvent A, et al. Among authors: hum dw. J Lipid Res. 2004 Nov;45(11):2110-5. doi: 10.1194/jlr.M400221-JLR200. Epub 2004 Sep 1. J Lipid Res. 2004. PMID: 15342685 Free article.
81 results