McLeish MJ - Search Results

1

Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes.

Andrews FH, McLeish MJ. Andrews FH, et al. Among authors: mcleish mj. FEBS J. 2013 Dec;280(24):6395-411. doi: 10.1111/febs.12459. Epub 2013 Aug 23. FEBS J. 2013. PMID: 23895593 Free article. Review.

2

Substrate specificity in thiamin diphosphate-dependent decarboxylases.

Andrews FH, McLeish MJ. Andrews FH, et al. Among authors: mcleish mj. Bioorg Chem. 2012 Aug;43:26-36. doi: 10.1016/j.bioorg.2011.12.001. Epub 2011 Dec 30. Bioorg Chem. 2012. PMID: 22245019 Review.

3

A bulky hydrophobic residue is not required to maintain the V-conformation of enzyme-bound thiamin diphosphate.

Andrews FH, Tom AR, Gunderman PR, Novak WR, McLeish MJ. Andrews FH, et al. Among authors: mcleish mj. Biochemistry. 2013 May 7;52(18):3028-30. doi: 10.1021/bi400368j. Epub 2013 Apr 23. Biochemistry. 2013. PMID: 23607689

4

Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer.

Andrews FH, Rogers MP, Paul LN, McLeish MJ. Andrews FH, et al. Among authors: mcleish mj. Biochemistry. 2014 Jul 15;53(27):4358-67. doi: 10.1021/bi500081r. Epub 2014 Jul 3. Biochemistry. 2014. PMID: 24956165 Free PMC article.

5

The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes.

Andrews FH, Horton JD, Shin D, Yoon HJ, Logsdon MG, Malik AM, Rogers MP, Kneen MM, Suh SW, McLeish MJ. Andrews FH, et al. Among authors: mcleish mj. Biochim Biophys Acta. 2015 Aug;1854(8):1001-9. doi: 10.1016/j.bbapap.2015.04.027. Epub 2015 Apr 30. Biochim Biophys Acta. 2015. PMID: 25936776

6

Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomyces cerevisiae.

Kneen MM, Stan R, Yep A, Tyler RP, Saehuan C, McLeish MJ. Kneen MM, et al. Among authors: mcleish mj. FEBS J. 2011 Jun;278(11):1842-53. doi: 10.1111/j.1742-4658.2011.08103.x. Epub 2011 Apr 18. FEBS J. 2011. PMID: 21501384 Free article.

7

Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies.

Patel H, Nemeria NS, Andrews FH, McLeish MJ, Jordan F. Patel H, et al. Among authors: mcleish mj. Biochemistry. 2014 Apr 8;53(13):2145-52. doi: 10.1021/bi4015743. Epub 2014 Mar 26. Biochemistry. 2014. PMID: 24628377 Free PMC article.

8

Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis.

Pallitsch K, Rogers MP, Andrews FH, Hammerschmidt F, McLeish MJ. Pallitsch K, et al. Among authors: mcleish mj. Bioorg Med Chem. 2017 Aug 15;25(16):4368-4374. doi: 10.1016/j.bmc.2017.06.013. Epub 2017 Jun 13. Bioorg Med Chem. 2017. PMID: 28693916

9

Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.

Polovnikova ES, McLeish MJ, Sergienko EA, Burgner JT, Anderson NL, Bera AK, Jordan F, Kenyon GL, Hasson MS. Polovnikova ES, et al. Among authors: mcleish mj. Biochemistry. 2003 Feb 25;42(7):1820-30. doi: 10.1021/bi026490k. Biochemistry. 2003. PMID: 12590569

10

The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes.

Hasson MS, Muscate A, McLeish MJ, Polovnikova LS, Gerlt JA, Kenyon GL, Petsko GA, Ringe D. Hasson MS, et al. Among authors: mcleish mj. Biochemistry. 1998 Jul 14;37(28):9918-30. doi: 10.1021/bi973047e. Biochemistry. 1998. PMID: 9665697

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