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A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation.
Psychosis Endophenotypes International Consortium; Wellcome Trust Case-Control Consortium 2; Bramon E, Pirinen M, Strange A, Lin K, Freeman C, Bellenguez C, Su Z, Band G, Pearson R, Vukcevic D, Langford C, Deloukas P, Hunt S, Gray E, Dronov S, Potter SC, Tashakkori-Ghanbaria A, Edkins S, Bumpstead SJ, Arranz MJ, Bakker S, Bender S, Bruggeman R, Cahn W, Chandler D, Collier DA, Crespo-Facorro B, Dazzan P, de Haan L, Di Forti M, Dragović M, Giegling I, Hall J, Iyegbe C, Jablensky A, Kahn RS, Kalaydjieva L, Kravariti E, Lawrie S, Linszen DH, Mata I, McDonald C, McIntosh A, Myin-Germeys I, Ophoff RA, Pariante CM, Paunio T, Picchioni M; Psychiatric Genomics Consortium; Ripke S, Rujescu D, Sauer H, Shaikh M, Sussmann J, Suvisaari J, Tosato S, Toulopoulou T, Van Os J, Walshe M, Weisbrod M, Whalley H, Wiersma D, Blackwell JM, Brown MA, Casas JP, Corvin A, Duncanson A, Jankowski JA, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Wood NW, Barroso I, Peltonen L, Lewis CM, Murray RM, Donnelly P, Powell J, Spencer CC. Psychosis Endophenotypes International Consortium, et al. Biol Psychiatry. 2014 Mar 1;75(5):386-97. doi: 10.1016/j.biopsych.2013.03.033. Epub 2013 Jul 17. Biol Psychiatry. 2014. PMID: 23871474 Free PMC article.
Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosis.
Crespo-Facorro B, Roiz-Santiáñez R, Pelayo-Terán JM, Pérez-Iglesias R, Carrasco-Marín E, Mata I, González-Mandly A, Jorge R, Vázquez-Barquero JL. Crespo-Facorro B, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Oct 1;31(7):1514-8. doi: 10.1016/j.pnpbp.2007.07.011. Epub 2007 Jul 18. Prog Neuropsychopharmacol Biol Psychiatry. 2007. PMID: 17706335
451 results