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Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC; Sanger Institute Mouse Genetics Project; Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP. White JK, et al. Among authors: tsang sh. Cell. 2013 Jul 18;154(2):452-64. doi: 10.1016/j.cell.2013.06.022. Cell. 2013. PMID: 23870131 Free PMC article.
Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.
McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project; Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ. McIntyre RE, et al. Among authors: tsang sh. PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15. PLoS Genet. 2012. PMID: 23166506 Free PMC article.
Mcph1-deficient mice reveal a role for MCPH1 in otitis media.
Chen J, Ingham N, Clare S, Raisen C, Vancollie VE, Ismail O, McIntyre RE, Tsang SH, Mahajan VB, Dougan G, Adams DJ, White JK, Steel KP. Chen J, et al. Among authors: tsang sh. PLoS One. 2013;8(3):e58156. doi: 10.1371/journal.pone.0058156. Epub 2013 Mar 13. PLoS One. 2013. PMID: 23516444 Free PMC article.
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss.
Chen J, Ingham N, Kelly J, Jadeja S, Goulding D, Pass J, Mahajan VB, Tsang SH, Nijnik A, Jackson IJ, White JK, Forge A, Jagger D, Steel KP. Chen J, et al. Among authors: tsang sh. PLoS Genet. 2014 Oct 30;10(10):e1004688. doi: 10.1371/journal.pgen.1004688. eCollection 2014 Oct. PLoS Genet. 2014. PMID: 25356849 Free PMC article.
Genome Surgery and Gene Therapy in Retinal Disorders.
Chan L, Mahajan VB, Tsang SH. Chan L, et al. Among authors: tsang sh. Yale J Biol Med. 2017 Dec 19;90(4):523-532. eCollection 2017 Dec. Yale J Biol Med. 2017. PMID: 29259518 Free PMC article. Review.
Gene therapy and genome surgery in the retina.
DiCarlo JE, Mahajan VB, Tsang SH. DiCarlo JE, et al. Among authors: tsang sh. J Clin Invest. 2018 Jun 1;128(6):2177-2188. doi: 10.1172/JCI120429. Epub 2018 Jun 1. J Clin Invest. 2018. PMID: 29856367 Free PMC article. Review.
564 results