Roberts TM - Search Results

1

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, Zhu P. Korpal M, et al. Among authors: roberts tm. Cancer Discov. 2013 Sep;3(9):1030-43. doi: 10.1158/2159-8290.CD-13-0142. Epub 2013 Jul 10. Cancer Discov. 2013. PMID: 23842682

2

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR. Ramaswamy S, et al. Among authors: roberts tm. Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5. doi: 10.1073/pnas.96.5.2110. Proc Natl Acad Sci U S A. 1999. PMID: 10051603 Free PMC article.

3

A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells.

Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA. Kau TR, et al. Among authors: roberts tm. Cancer Cell. 2003 Dec;4(6):463-76. doi: 10.1016/s1535-6108(03)00303-9. Cancer Cell. 2003. PMID: 14706338 Free article.

4

Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells.

Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC. Berger R, et al. Among authors: roberts tm. Cancer Res. 2004 Dec 15;64(24):8867-75. doi: 10.1158/0008-5472.CAN-04-2938. Cancer Res. 2004. PMID: 15604246

5

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA. Johannessen CM, et al. Among authors: roberts tm. Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627. Epub 2010 Nov 24. Nature. 2010. PMID: 21107320 Free PMC article.

6

Functional characterization of an isoform-selective inhibitor of PI3K-p110β as a potential anticancer agent.

Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Ni J, et al. Cancer Discov. 2012 May;2(5):425-33. doi: 10.1158/2159-8290.CD-12-0003. Epub 2012 Apr 12. Cancer Discov. 2012. PMID: 22588880 Free PMC article.

7

K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.

Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, Schmelzle T, Lai A, Brachmann SM, Bentires-Alj M, Roberts TM, Sellers WR, Hofmann F, Maira SM. Hofmann I, et al. Among authors: roberts tm. PLoS One. 2012;7(8):e44146. doi: 10.1371/journal.pone.0044146. Epub 2012 Aug 31. PLoS One. 2012. PMID: 22952903 Free PMC article.

8

Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention.

Jia S, Gao X, Lee SH, Maira SM, Wu X, Stack EC, Signoretti S, Loda M, Zhao JJ, Roberts TM. Jia S, et al. Among authors: roberts tm. Cancer Discov. 2013 Jan;3(1):44-51. doi: 10.1158/2159-8290.CD-12-0262. Epub 2012 Dec 20. Cancer Discov. 2013. PMID: 23258246 Free PMC article.

9

The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type.

Utermark T, Schmit F, Lee SH, Gao X, Schaffhausen BS, Roberts TM. Utermark T, et al. Among authors: roberts tm. J Virol. 2014 Sep;88(18):10673-9. doi: 10.1128/JVI.01409-14. Epub 2014 Jul 2. J Virol. 2014. PMID: 24991009 Free PMC article.

10

The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.

Wang H, Nicolay BN, Chick JM, Gao X, Geng Y, Ren H, Gao H, Yang G, Williams JA, Suski JM, Keibler MA, Sicinska E, Gerdemann U, Haining WN, Roberts TM, Polyak K, Gygi SP, Dyson NJ, Sicinski P. Wang H, et al. Among authors: roberts tm. Nature. 2017 Jun 15;546(7658):426-430. doi: 10.1038/nature22797. Epub 2017 Jun 7. Nature. 2017. PMID: 28607489 Free PMC article.

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