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Defective decatenation checkpoint function is a common feature of melanoma.
Brooks K, Chia KM, Spoerri L, Mukhopadhyay P, Wigan M, Stark M, Pavey S, Gabrielli B. Brooks K, et al. Among authors: spoerri l. J Invest Dermatol. 2014 Jan;134(1):150-158. doi: 10.1038/jid.2013.264. Epub 2013 Jun 13. J Invest Dermatol. 2014. PMID: 23842115 Free article.
Decatenation checkpoint-defective melanomas are dependent on PI3K for survival.
Brooks K, Ranall M, Spoerri L, Stevenson A, Gunasingh G, Pavey S, Meunier F, Gonda TJ, Gabrielli B. Brooks K, et al. Among authors: spoerri l. Pigment Cell Melanoma Res. 2014 Sep;27(5):813-21. doi: 10.1111/pcmr.12268. Epub 2014 Jun 23. Pigment Cell Melanoma Res. 2014. PMID: 24890688
Endogenous Replication Stress Marks Melanomas Sensitive to CHEK1 Inhibitors In Vivo.
Oo ZY, Stevenson AJ, Proctor M, Daignault SM, Walpole S, Lanagan C, Chen J, Škalamera D, Spoerri L, Ainger SA, Sturm RA, Haass NK, Gabrielli B. Oo ZY, et al. Among authors: spoerri l. Clin Cancer Res. 2018 Jun 15;24(12):2901-2912. doi: 10.1158/1078-0432.CCR-17-2701. Epub 2018 Mar 13. Clin Cancer Res. 2018. PMID: 29535131
NFIB Mediates BRN2 Driven Melanoma Cell Migration and Invasion Through Regulation of EZH2 and MITF.
Fane ME, Chhabra Y, Hollingsworth DEJ, Simmons JL, Spoerri L, Oh TG, Chauhan J, Chin T, Harris L, Harvey TJ, Muscat GEO, Goding CR, Sturm RA, Haass NK, Boyle GM, Piper M, Smith AG. Fane ME, et al. Among authors: spoerri l. EBioMedicine. 2017 Feb;16:63-75. doi: 10.1016/j.ebiom.2017.01.013. Epub 2017 Jan 16. EBioMedicine. 2017. PMID: 28119061 Free PMC article.
Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure.
Smith MP, Rowling EJ, Miskolczi Z, Ferguson J, Spoerri L, Haass NK, Sloss O, McEntegart S, Arozarena I, von Kriegsheim A, Rodriguez J, Brunton H, Kmarashev J, Levesque MP, Dummer R, Frederick DT, Andrews MC, Cooper ZA, Flaherty KT, Wargo JA, Wellbrock C. Smith MP, et al. Among authors: spoerri l. EMBO Mol Med. 2017 Aug;9(8):1011-1029. doi: 10.15252/emmm.201607156. EMBO Mol Med. 2017. PMID: 28606996 Free PMC article.
16 results