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Carcinoma cells misuse the host tissue damage response to invade the brain.
Chuang HN, van Rossum D, Sieger D, Siam L, Klemm F, Bleckmann A, Bayerlová M, Farhat K, Scheffel J, Schulz M, Dehghani F, Stadelmann C, Hanisch UK, Binder C, Pukrop T. Chuang HN, et al. Glia. 2013 Aug;61(8):1331-46. doi: 10.1002/glia.22518. Epub 2013 Jul 6. Glia. 2013. PMID: 23832647 Free PMC article.
Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.
Scheffel J, Regen T, Van Rossum D, Seifert S, Ribes S, Nau R, Parsa R, Harris RA, Boddeke HW, Chuang HN, Pukrop T, Wessels JT, Jürgens T, Merkler D, Brück W, Schnaars M, Simons M, Kettenmann H, Hanisch UK. Scheffel J, et al. Among authors: chuang hn. Glia. 2012 Dec;60(12):1930-43. doi: 10.1002/glia.22409. Epub 2012 Aug 21. Glia. 2012. PMID: 22911652
β-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis.
Klemm F, Bleckmann A, Siam L, Chuang HN, Rietkötter E, Behme D, Schulz M, Schaffrinski M, Schindler S, Trümper L, Kramer F, Beissbarth T, Stadelmann C, Binder C, Pukrop T. Klemm F, et al. Among authors: chuang hn. Carcinogenesis. 2011 Mar;32(3):434-42. doi: 10.1093/carcin/bgq269. Epub 2010 Dec 20. Carcinogenesis. 2011. PMID: 21173432
Intralesional TLR4 agonist treatment strengthens the organ defense against colonizing cancer cells in the brain.
Blazquez R, Chuang HN, Wenske B, Trigueros L, Wlochowitz D, Liguori R, Ferrazzi F, Regen T, Proescholdt MA, Rohde V, Riemenschneider MJ, Stadelmann C, Bleckmann A, Beißbarth T, van Rossum D, Hanisch UK, Pukrop T. Blazquez R, et al. Among authors: chuang hn. Oncogene. 2022 Nov;41(46):5008-5019. doi: 10.1038/s41388-022-02496-3. Epub 2022 Oct 12. Oncogene. 2022. PMID: 36224342 Free PMC article.
PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression.
Hohensee I, Chuang HN, Grottke A, Werner S, Schulte A, Horn S, Lamszus K, Bartkowiak K, Witzel I, Westphal M, Matschke J, Glatzel M, Jücker M, Pukrop T, Pantel K, Wikman H. Hohensee I, et al. Among authors: chuang hn. Oncotarget. 2017 Jan 24;8(4):6155-6168. doi: 10.18632/oncotarget.14047. Oncotarget. 2017. PMID: 28008153 Free PMC article.
24 results