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BET proteins promote efficient murine leukemia virus integration at transcription start sites.
Sharma A, Larue RC, Plumb MR, Malani N, Male F, Slaughter A, Kessl JJ, Shkriabai N, Coward E, Aiyer SS, Green PL, Wu L, Roth MJ, Bushman FD, Kvaratskhelia M. Sharma A, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12036-41. doi: 10.1073/pnas.1307157110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818621 Free PMC article.
The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors.
Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. Feng L, et al. Among authors: sharma a. J Biol Chem. 2013 May 31;288(22):15813-20. doi: 10.1074/jbc.M112.443390. Epub 2013 Apr 24. J Biol Chem. 2013. PMID: 23615903 Free PMC article.
Altering murine leukemia virus integration through disruption of the integrase and BET protein family interaction.
Aiyer S, Swapna GV, Malani N, Aramini JM, Schneider WM, Plumb MR, Ghanem M, Larue RC, Sharma A, Studamire B, Kvaratskhelia M, Bushman FD, Montelione GT, Roth MJ. Aiyer S, et al. Among authors: sharma a. Nucleic Acids Res. 2014 May;42(9):5917-28. doi: 10.1093/nar/gku175. Epub 2014 Mar 12. Nucleic Acids Res. 2014. PMID: 24623816 Free PMC article.
A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. Sharma A, et al. PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24874515 Free PMC article.
Molecular mechanisms of retroviral integration site selection.
Kvaratskhelia M, Sharma A, Larue RC, Serrao E, Engelman A. Kvaratskhelia M, et al. Among authors: sharma a. Nucleic Acids Res. 2014;42(16):10209-25. doi: 10.1093/nar/gku769. Epub 2014 Aug 21. Nucleic Acids Res. 2014. PMID: 25147212 Free PMC article.
The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. Feng L, et al. Among authors: sharma a. ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2. ACS Chem Biol. 2016. PMID: 26910179 Free PMC article.
Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2.
Larue RC, Xing E, Kenney AD, Zhang Y, Tuazon JA, Li J, Yount JS, Li PK, Sharma A. Larue RC, et al. Among authors: sharma a. Bioconjug Chem. 2021 Jan 20;32(1):215-223. doi: 10.1021/acs.bioconjchem.0c00664. Epub 2020 Dec 24. Bioconjug Chem. 2021. PMID: 33356169 Free PMC article.
Development of Murine Leukemia Virus Integrase-Derived Peptides That Bind Brd4 Extra-Terminal Domain as Candidates for Suppression of Acute Myeloid Leukemia.
Xing E, Surendranathan N, Kong X, Cyberski N, Garcia JD, Cheng X, Sharma A, Li PK, Larue RC. Xing E, et al. Among authors: sharma a. ACS Pharmacol Transl Sci. 2021 Sep 10;4(5):1628-1638. doi: 10.1021/acsptsci.1c00159. eCollection 2021 Oct 8. ACS Pharmacol Transl Sci. 2021. PMID: 34661079 Free PMC article.
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