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Lysosome-mediated processing of chromatin in senescence.
Ivanov A, Pawlikowski J, Manoharan I, van Tuyn J, Nelson DM, Rai TS, Shah PP, Hewitt G, Korolchuk VI, Passos JF, Wu H, Berger SL, Adams PD. Ivanov A, et al. Among authors: korolchuk vi. J Cell Biol. 2013 Jul 8;202(1):129-43. doi: 10.1083/jcb.201212110. Epub 2013 Jul 1. J Cell Biol. 2013. PMID: 23816621 Free PMC article.
Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity.
Carroll B, Maetzel D, Maddocks OD, Otten G, Ratcliff M, Smith GR, Dunlop EA, Passos JF, Davies OR, Jaenisch R, Tee AR, Sarkar S, Korolchuk VI. Carroll B, et al. Among authors: korolchuk vi. Elife. 2016 Jan 7;5:e11058. doi: 10.7554/eLife.11058. Elife. 2016. PMID: 26742086 Free PMC article.
Mitochondria are required for pro-ageing features of the senescent phenotype.
Correia-Melo C, Marques FD, Anderson R, Hewitt G, Hewitt R, Cole J, Carroll BM, Miwa S, Birch J, Merz A, Rushton MD, Charles M, Jurk D, Tait SW, Czapiewski R, Greaves L, Nelson G, Bohlooly-Y M, Rodriguez-Cuenca S, Vidal-Puig A, Mann D, Saretzki G, Quarato G, Green DR, Adams PD, von Zglinicki T, Korolchuk VI, Passos JF. Correia-Melo C, et al. Among authors: korolchuk vi. EMBO J. 2016 Apr 1;35(7):724-42. doi: 10.15252/embj.201592862. Epub 2016 Feb 4. EMBO J. 2016. PMID: 26848154 Free PMC article.
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair.
Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, Passos JF, Korolchuk VI. Hewitt G, et al. Among authors: korolchuk vi. Autophagy. 2016 Oct 2;12(10):1917-1930. doi: 10.1080/15548627.2016.1210368. Epub 2016 Jul 8. Autophagy. 2016. PMID: 27391408 Free PMC article.
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Carroll B, et al. Among authors: korolchuk vi. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. J Cell Biol. 2017. PMID: 28566325 Free PMC article.
Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.
Carroll B, Otten EG, Manni D, Stefanatos R, Menzies FM, Smith GR, Jurk D, Kenneth N, Wilkinson S, Passos JF, Attems J, Veal EA, Teyssou E, Seilhean D, Millecamps S, Eskelinen EL, Bronowska AK, Rubinsztein DC, Sanz A, Korolchuk VI. Carroll B, et al. Among authors: korolchuk vi. Nat Commun. 2018 Jan 17;9(1):256. doi: 10.1038/s41467-017-02746-z. Nat Commun. 2018. PMID: 29343728 Free PMC article.
Rapamycin improves healthspan but not inflammaging in nfκb1-/- mice.
Correia-Melo C, Birch J, Fielder E, Rahmatika D, Taylor J, Chapman J, Lagnado A, Carroll BM, Miwa S, Richardson G, Jurk D, Oakley F, Mann J, Mann DA, Korolchuk VI, Passos JF. Correia-Melo C, et al. Among authors: korolchuk vi. Aging Cell. 2019 Feb;18(1):e12882. doi: 10.1111/acel.12882. Epub 2018 Nov 23. Aging Cell. 2019. PMID: 30468013 Free PMC article.
mTORC1 activity is supported by spatial association with focal adhesions.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. Rabanal-Ruiz Y, et al. Among authors: korolchuk vi. J Cell Biol. 2021 May 3;220(5):e202004010. doi: 10.1083/jcb.202004010. J Cell Biol. 2021. PMID: 33635313 Free PMC article.
93 results