Sarafianos SG - Search Results

1

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.

Michailidis E, Ryan EM, Hachiya A, Kirby KA, Marchand B, Leslie MD, Huber AD, Ong YT, Jackson JC, Singh K, Kodama EN, Mitsuya H, Parniak MA, Sarafianos SG. Michailidis E, et al. Among authors: sarafianos sg. Retrovirology. 2013 Jun 24;10:65. doi: 10.1186/1742-4690-10-65. Retrovirology. 2013. PMID: 23800377 Free PMC article.

2

Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.

Mu L, Sarafianos SG, Nicklaus MC, Russ P, Siddiqui MA, Ford H Jr, Mitsuya H, Le R, Kodama E, Meier C, Knispel T, Anderson L, Barchi JJ Jr, Marquez VE. Mu L, et al. Among authors: sarafianos sg. Biochemistry. 2000 Sep 19;39(37):11205-15. doi: 10.1021/bi001090n. Biochemistry. 2000. PMID: 10985766

3

HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.

Himmel DM, Sarafianos SG, Dharmasena S, Hossain MM, McCoy-Simandle K, Ilina T, Clark AD Jr, Knight JL, Julias JG, Clark PK, Krogh-Jespersen K, Levy RM, Hughes SH, Parniak MA, Arnold E. Himmel DM, et al. Among authors: sarafianos sg. ACS Chem Biol. 2006 Dec 20;1(11):702-12. doi: 10.1021/cb600303y. ACS Chem Biol. 2006. PMID: 17184135 Free PMC article.

4

3'-Azido-3'-deoxythymidine-(5')-tetraphospho-(5')-adenosine, the product of ATP-mediated excision of chain-terminating AZTMP, is a potent chain-terminating substrate for HIV-1 reverse transcriptase.

Dharmasena S, Pongracz Z, Arnold E, Sarafianos SG, Parniak MA. Dharmasena S, et al. Among authors: sarafianos sg. Biochemistry. 2007 Jan 23;46(3):828-36. doi: 10.1021/bi061364s. Biochemistry. 2007. PMID: 17223704

5

Synthesis of AZTpSpCX2ppSA and AZTpSpCX2ppSAZT: hydrolysis-resistant potential inhibitors of the AZT excision reaction of HIV-1 RT.

Han Q, Sarafianos SG, Arnold E, Parniak MA, Gaffney BL, Jones RA. Han Q, et al. Among authors: sarafianos sg. Org Lett. 2007 Dec 6;9(25):5243-6. doi: 10.1021/ol7023746. Epub 2007 Nov 8. Org Lett. 2007. PMID: 17988141

6

Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.

Hachiya A, Kodama EN, Sarafianos SG, Schuckmann MM, Sakagami Y, Matsuoka M, Takiguchi M, Gatanaga H, Oka S. Hachiya A, et al. Among authors: sarafianos sg. J Virol. 2008 Apr;82(7):3261-70. doi: 10.1128/JVI.01154-07. Epub 2008 Jan 23. J Virol. 2008. PMID: 18216099 Free PMC article.

7

2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.

Kawamoto A, Kodama E, Sarafianos SG, Sakagami Y, Kohgo S, Kitano K, Ashida N, Iwai Y, Hayakawa H, Nakata H, Mitsuya H, Arnold E, Matsuoka M. Kawamoto A, et al. Among authors: sarafianos sg. Int J Biochem Cell Biol. 2008;40(11):2410-20. doi: 10.1016/j.biocel.2008.04.007. Epub 2008 Apr 11. Int J Biochem Cell Biol. 2008. PMID: 18487070

8

Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.

Sarafianos SG, Marchand B, Das K, Himmel DM, Parniak MA, Hughes SH, Arnold E. Sarafianos SG, et al. J Mol Biol. 2009 Jan 23;385(3):693-713. doi: 10.1016/j.jmb.2008.10.071. Epub 2008 Nov 3. J Mol Biol. 2009. PMID: 19022262 Free PMC article. Review.

9

Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20.

Izumi K, Kodama E, Shimura K, Sakagami Y, Watanabe K, Ito S, Watabe T, Terakawa Y, Nishikawa H, Sarafianos SG, Kitaura K, Oishi S, Fujii N, Matsuoka M. Izumi K, et al. Among authors: sarafianos sg. J Biol Chem. 2009 Feb 20;284(8):4914-20. doi: 10.1074/jbc.M807169200. Epub 2008 Dec 10. J Biol Chem. 2009. PMID: 19073606 Free PMC article.

10

SC29EK, a peptide fusion inhibitor with enhanced alpha-helicity, inhibits replication of human immunodeficiency virus type 1 mutants resistant to enfuvirtide.

Naito T, Izumi K, Kodama E, Sakagami Y, Kajiwara K, Nishikawa H, Watanabe K, Sarafianos SG, Oishi S, Fujii N, Matsuoka M. Naito T, et al. Among authors: sarafianos sg. Antimicrob Agents Chemother. 2009 Mar;53(3):1013-8. doi: 10.1128/AAC.01211-08. Epub 2008 Dec 29. Antimicrob Agents Chemother. 2009. PMID: 19114674 Free PMC article.

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