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Polymorphic fibrillation of the destabilized fourth fasciclin-1 domain mutant A546T of the Transforming growth factor-β-induced protein (TGFBIp) occurs through multiple pathways with different oligomeric intermediates.
Andreasen M, Nielsen SB, Runager K, Christiansen G, Nielsen NC, Enghild JJ, Otzen DE. Andreasen M, et al. Among authors: nielsen sb, nielsen nc. J Biol Chem. 2012 Oct 5;287(41):34730-42. doi: 10.1074/jbc.M112.379552. Epub 2012 Aug 14. J Biol Chem. 2012. PMID: 22893702 Free PMC article.
How epigallocatechin gallate can inhibit α-synuclein oligomer toxicity in vitro.
Lorenzen N, Nielsen SB, Yoshimura Y, Vad BS, Andersen CB, Betzer C, Kaspersen JD, Christiansen G, Pedersen JS, Jensen PH, Mulder FA, Otzen DE. Lorenzen N, et al. Among authors: nielsen sb. J Biol Chem. 2014 Aug 1;289(31):21299-310. doi: 10.1074/jbc.M114.554667. Epub 2014 Jun 6. J Biol Chem. 2014. PMID: 24907278 Free PMC article.
The role of stable α-synuclein oligomers in the molecular events underlying amyloid formation.
Lorenzen N, Nielsen SB, Buell AK, Kaspersen JD, Arosio P, Vad BS, Paslawski W, Christiansen G, Valnickova-Hansen Z, Andreasen M, Enghild JJ, Pedersen JS, Dobson CM, Knowles TP, Otzen DE. Lorenzen N, et al. Among authors: nielsen sb. J Am Chem Soc. 2014 Mar 12;136(10):3859-68. doi: 10.1021/ja411577t. Epub 2014 Feb 28. J Am Chem Soc. 2014. PMID: 24527756
Modulation of fibrillation of hIAPP core fragments by chemical modification of the peptide backbone.
Andreasen M, Nielsen SB, Mittag T, Bjerring M, Nielsen JT, Zhang S, Nielsen EH, Jeppesen M, Christiansen G, Besenbacher F, Dong M, Nielsen NC, Skrydstrup T, Otzen DE. Andreasen M, et al. Among authors: nielsen sb, nielsen jt, nielsen nc, nielsen eh. Biochim Biophys Acta. 2012 Feb;1824(2):274-85. doi: 10.1016/j.bbapap.2011.10.014. Epub 2011 Oct 29. Biochim Biophys Acta. 2012. PMID: 22064122
Role of elongation and secondary pathways in S6 amyloid fibril growth.
Lorenzen N, Cohen SI, Nielsen SB, Herling TW, Christiansen G, Dobson CM, Knowles TP, Otzen D. Lorenzen N, et al. Among authors: nielsen sb. Biophys J. 2012 May 2;102(9):2167-75. doi: 10.1016/j.bpj.2012.03.047. Biophys J. 2012. PMID: 22824281 Free PMC article.
Multiple roles of heparin in the aggregation of p25α.
Nielsen SB, Yde P, Giehm L, Sundbye S, Christiansen G, Mathiesen J, Jensen MH, Jensen PH, Otzen DE. Nielsen SB, et al. J Mol Biol. 2012 Aug 24;421(4-5):601-15. doi: 10.1016/j.jmb.2012.01.050. Epub 2012 Feb 3. J Mol Biol. 2012. PMID: 22326478
High stability and cooperative unfolding of α-synuclein oligomers.
Paslawski W, Andreasen M, Nielsen SB, Lorenzen N, Thomsen K, Kaspersen JD, Pedersen JS, Otzen DE. Paslawski W, et al. Among authors: nielsen sb. Biochemistry. 2014 Oct 7;53(39):6252-63. doi: 10.1021/bi5007833. Epub 2014 Sep 24. Biochemistry. 2014. PMID: 25216651
161 results