Fishwick CW - Search Results

1

An in silico structure-based approach to anti-infective drug discovery.

Cunningham F, McPhillie MJ, Johnson AP, Fishwick CW. Cunningham F, et al. Among authors: fishwick cw. Parasitology. 2014 Jan;141(1):17-27. doi: 10.1017/S0031182013000693. Epub 2013 Jun 17. Parasitology. 2014. PMID: 23768800 Review.

2

Macrocyclic inhibitors of the bacterial cell wall biosynthesis enzyme MurD.

Horton JR, Bostock JM, Chopra I, Hesse L, Phillips SE, Adams DJ, Johnson AP, Fishwick CW. Horton JR, et al. Among authors: fishwick cw. Bioorg Med Chem Lett. 2003 May 5;13(9):1557-60. doi: 10.1016/s0960-894x(03)00176-8. Bioorg Med Chem Lett. 2003. PMID: 12699754

3

A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli.

Besong GE, Bostock JM, Stubbings W, Chopra I, Roper DI, Lloyd AJ, Fishwick CW, Johnson AP. Besong GE, et al. Among authors: fishwick cw. Angew Chem Int Ed Engl. 2005 Oct 7;44(39):6403-6. doi: 10.1002/anie.200501662. Angew Chem Int Ed Engl. 2005. PMID: 16158456 No abstract available.

4

The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

Heikkilä T, Thirumalairajan S, Davies M, Parsons MR, McConkey AG, Fishwick CW, Johnson AP. Heikkilä T, et al. Among authors: fishwick cw. Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. doi: 10.1016/j.bmcl.2005.09.045. Epub 2005 Oct 19. Bioorg Med Chem Lett. 2006. PMID: 16236496

5

Design and synthesis of potent inhibitors of the malaria parasite dihydroorotate dehydrogenase.

Heikkilä T, Ramsey C, Davies M, Galtier C, Stead AM, Johnson AP, Fishwick CW, Boa AN, McConkey GA. Heikkilä T, et al. Among authors: fishwick cw. J Med Chem. 2007 Jan 25;50(2):186-91. doi: 10.1021/jm060687j. J Med Chem. 2007. PMID: 17228860

6

Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases.

Davies M, Heikkilä T, McConkey GA, Fishwick CW, Parsons MR, Johnson AP. Davies M, et al. Among authors: fishwick cw. J Med Chem. 2009 May 14;52(9):2683-93. doi: 10.1021/jm800963t. J Med Chem. 2009. PMID: 19351152

7

Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening.

Yi Mok N, Chadwick J, Kellett KA, Hooper NM, Johnson AP, Fishwick CW. Yi Mok N, et al. Among authors: fishwick cw. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6770-4. doi: 10.1016/j.bmcl.2009.09.103. Epub 2009 Oct 2. Bioorg Med Chem Lett. 2009. PMID: 19854048

8

A study of the effects of substituents on the selectivity of the binding of N-arylaminomethylene malonate inhibitors to DHODH.

Cowen D, Bedingfield P, McConkey GA, Fishwick CW, Johnson AP. Cowen D, et al. Among authors: fishwick cw. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1284-7. doi: 10.1016/j.bmcl.2009.11.079. Epub 2009 Nov 27. Bioorg Med Chem Lett. 2010. PMID: 20034791

9

Structure-based discovery of antibacterial drugs.

Simmons KJ, Chopra I, Fishwick CW. Simmons KJ, et al. Among authors: fishwick cw. Nat Rev Microbiol. 2010 Jul;8(7):501-10. doi: 10.1038/nrmicro2349. Nat Rev Microbiol. 2010. PMID: 20551974 Review.

10

Structure-based design of anti-infectives.

Agarwal AK, Fishwick CW. Agarwal AK, et al. Among authors: fishwick cw. Ann N Y Acad Sci. 2010 Dec;1213:20-45. doi: 10.1111/j.1749-6632.2010.05859.x. Ann N Y Acad Sci. 2010. PMID: 21175675 Review.

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