Vassar RJ - Search Results

1

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.

Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA. Frost JL, et al. Among authors: vassar rj. Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7. Am J Pathol. 2013. PMID: 23747948 Free PMC article.

2

APP mouse models for Alzheimer's disease preclinical studies.

Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. Sasaguri H, et al. EMBO J. 2017 Sep 1;36(17):2473-2487. doi: 10.15252/embj.201797397. Epub 2017 Aug 1. EMBO J. 2017. PMID: 28768718 Free PMC article. Review.

3

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model.

Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Rice HC, et al. Mol Neurodegener. 2020 Jan 8;15(1):3. doi: 10.1186/s13024-019-0356-y. Mol Neurodegener. 2020. PMID: 31915042 Free PMC article.

4

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Kukreja L, et al. Mol Neurodegener. 2014 May 2;9:16. doi: 10.1186/1750-1326-9-16. Mol Neurodegener. 2014. PMID: 24885175 Free PMC article.

5

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Sadleir KR, et al. Among authors: vassar r. PLoS One. 2014 Jul 3;9(7):e101643. doi: 10.1371/journal.pone.0101643. eCollection 2014. PLoS One. 2014. PMID: 24992504 Free PMC article.

6

Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.

Liao F, Zhang TJ, Jiang H, Lefton KB, Robinson GO, Vassar R, Sullivan PM, Holtzman DM. Liao F, et al. Acta Neuropathol Commun. 2015 Nov 10;3:70. doi: 10.1186/s40478-015-0250-y. Acta Neuropathol Commun. 2015. PMID: 26556230 Free PMC article.

7

HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation.

Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, Gill AJ, Kolson DL, Diehl JA, Mankowski JL, Jordan-Sciutto KL. Gannon PJ, et al. Am J Pathol. 2017 Jan;187(1):91-109. doi: 10.1016/j.ajpath.2016.09.006. Am J Pathol. 2017. PMID: 27993242 Free PMC article.

8

Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.

Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. Liu P, et al. J Alzheimers Dis. 2017;56(2):743-761. doi: 10.3233/JAD-161027. J Alzheimers Dis. 2017. PMID: 28059792 Free PMC article.

9

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease.

Sadleir KR, Popovic J, Vassar R. Sadleir KR, et al. J Biol Chem. 2018 Nov 30;293(48):18434-18443. doi: 10.1074/jbc.RA118.005769. Epub 2018 Oct 12. J Biol Chem. 2018. PMID: 30315100 Free PMC article.

10

A promising, novel, and unique BACE1 inhibitor emerges in the quest to prevent Alzheimer's disease.

Dobrowolska Zakaria JA, Vassar RJ. Dobrowolska Zakaria JA, et al. Among authors: vassar rj. EMBO Mol Med. 2018 Nov;10(11):e9717. doi: 10.15252/emmm.201809717. EMBO Mol Med. 2018. PMID: 30322841 Free PMC article.

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