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330 results

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Locked nucleic acid: modality, diversity, and drug discovery.
Hagedorn PH, Persson R, Funder ED, Albæk N, Diemer SL, Hansen DJ, Møller MR, Papargyri N, Christiansen H, Hansen BR, Hansen HF, Jensen MA, Koch T. Hagedorn PH, et al. Among authors: persson r. Drug Discov Today. 2018 Jan;23(1):101-114. doi: 10.1016/j.drudis.2017.09.018. Epub 2017 Oct 6. Drug Discov Today. 2018. PMID: 28988994 Free article. Review.
Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.
van Poelgeest EP, Hodges MR, Moerland M, Tessier Y, Levin AA, Persson R, Lindholm MW, Dumong Erichsen K, Ørum H, Cohen AF, Burggraaf J. van Poelgeest EP, et al. Among authors: persson r. Br J Clin Pharmacol. 2015 Dec;80(6):1350-61. doi: 10.1111/bcp.12738. Epub 2015 Oct 24. Br J Clin Pharmacol. 2015. PMID: 26261033 Free PMC article. Clinical Trial.
From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides.
Braendli-Baiocco A, Festag M, Dumong Erichsen K, Persson R, Mihatsch MJ, Fisker N, Funk J, Mohr S, Constien R, Ploix C, Brady K, Berrera M, Altmann B, Lenz B, Albassam M, Schmitt G, Weiser T, Schuler F, Singer T, Tessier Y. Braendli-Baiocco A, et al. Among authors: persson r. Toxicol Sci. 2017 May 1;157(1):112-128. doi: 10.1093/toxsci/kfx025. Toxicol Sci. 2017. PMID: 28123102 Free PMC article.
Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo.
Javanbakht H, Mueller H, Walther J, Zhou X, Lopez A, Pattupara T, Blaising J, Pedersen L, Albæk N, Jackerott M, Shi T, Ploix C, Driessen W, Persson R, Ravn J, Young JAT, Ottosen S. Javanbakht H, et al. Among authors: persson r. Mol Ther Nucleic Acids. 2018 Jun 1;11:441-454. doi: 10.1016/j.omtn.2018.02.005. Epub 2018 Feb 23. Mol Ther Nucleic Acids. 2018. PMID: 29858079 Free PMC article.
Treatment of HCV infection by targeting microRNA.
Janssen HL, Reesink HW, Lawitz EJ, Zeuzem S, Rodriguez-Torres M, Patel K, van der Meer AJ, Patick AK, Chen A, Zhou Y, Persson R, King BD, Kauppinen S, Levin AA, Hodges MR. Janssen HL, et al. Among authors: persson r. N Engl J Med. 2013 May 2;368(18):1685-94. doi: 10.1056/NEJMoa1209026. Epub 2013 Mar 27. N Engl J Med. 2013. PMID: 23534542 Free article. Clinical Trial.
330 results